The Safety of 2-ThiazolaMine, 4-(4-chloro-2-thienyl)-

Introduction:

2-Thiazolamine, also known as thiophene-2-amine, is a derivative of thiophene, which is a heterocyclic aromatic compound with a sulfur atom as one of its ring heteroatoms.
4-(4-chloro-2-thienyl)-2-thiazolamine, also known as chlorpheniramine maleate, is a synthetic compound that is used as a pharmaceutical intermediate and as a chemical reagent in various industrial applications.
In this article, we will discuss the safety of 4-(4-chloro-2-thienyl)-2-thiazolamine, focusing on its use in the chemical industry.

Chemical Properties:

4-(4-chloro-2-thienyl)-2-thiazolamine is a white to off-white solid that has a melting point of 143-145°C.
It is soluble in water and has a logP value of 3.
22.
LogP is a measure of a compound's hydrophobic-hydrophilic balance, which indicates its ability to partition between water and organic solvents.
4-(4-chloro-2-thienyl)-2-thiazolamine is slightly soluble in ethanol and acetone, but it is very soluble in methanol and ethyl acetate.

4-(4-chloro-2-thienyl)-2-thiazolamine is a basic compound with a pKa value of 9.
6.
It is also hygroscopic, meaning that it absorbs moisture from the air, which can affect its stability and handling.

Toxicity:

4-(4-chloro-2-thienyl)-2-thiazolamine is classified as a Category 3 respiratory sensitizer according to the Globally Harmonized System (GHS) of classification and labeling of chemicals.
This means that it has the potential to cause skin sensitization and respiratory problems in humans.

Inhalation of high concentrations of 4-(4-chloro-2-thienyl)-2-thiazolamine vapor can cause irritation of the respiratory system, including coughing, wheezing, and shortness of breath.
Prolonged exposure to the vapor may also cause chronic obstructive pulmonary disease (COPD).

Skin contact with 4-(4-chloro-2-thienyl)-2-thiazolamine can cause skin irritation, including redness, itching, and blistering.
Prolonged exposure to the skin may also cause allergic reactions.

Ingestion of 4-(4-chloro-2-thienyl)-2-thiazolamine can cause gastrointestinal symptoms, including nausea, vomiting, and diarrhea.
It may also cause effects on the liver and kidneys, including jaundice and nephritis.

Fire and Explosion Hazards:

4-(4-chloro-2-thienyl)-2-thiazolamine is not classified as a fire hazard according to the National Fire Protection Association (NFPA) or the United Nations (UN) classification systems.
However, it is a combustible solid and may burn if it comes into contact with an ignition source, such as an open flame or hot surface.

4-(4-chloro-2-thienyl)-2-thiazolamine is not classified as an explosive material according to the NFPA or UN classification systems.
However, it has a relatively high vapor pressure and may be subject to explosive boiling if it is heated sufficiently.

Handling and Storage:

4-(4-chloro-2-thienyl)-2-thiazolamine should be handled with caution, as it is a hazardous chemical.
It should be stored in a cool, dry place, away from