The role of superfine pulverizer in the field of traditional Chinese Medicine

1、 Ultrafine comminution is a basic processing technology in production and application It is also an important link in the pretreatment of raw materials of traditional Chinese medicine General crushing technology can only make the particle size of the material comminuted to 45 μ m, while modern ultra-fine grinding technology can comminute the material to 10 μ m, even 1 μ m ultra-fine powder Because of its large specific surface area, good solubility, dispersibility, adsorption and chemical reaction activity, ultrafine powder is widely used in clothing, food, medicine, cosmetics and other industries Under the background of modernization and modernization of traditional Chinese medicine, ultra micro comminution technology, with its own advantages, can make up for the defects of traditional comminution technology, improve the texture uniformity of powder, improve the bioavailability of drugs, accelerate the absorption of drugs by the body and enhance the efficacy, so as to improve the application potential of traditional Chinese medicine resources In this industry, it has shown its unique advantages and broad application prospects 。 2 The role of superfine grinding technology in the production and application of traditional Chinese medicine 1 Improve the dissolution rate and promote the extraction of effective ingredients The results showed that the particle size of the powder of Panax notoginseng was uniform and reached the cell level Compared with the common powder, the total content of Ginsenoside Rg1, Rb1, and Notoginsenoside R1 was 8.3%, which was 5.0% higher than that of the common powder Li MJ et al Studied the effect of superfine comminution technology on the extraction of Flavonoids from plantain The content of flavonoids in the superfine powder of plantain was extracted by ultrasonic The content of flavonoid glycosides was detected by reversed phase liquid chromatography The results showed that the extraction rate of flavonoids in the superfine powder of plantain was significantly higher than that of traditional powder The superfine comminution technology was helpful for the dissolution and extraction of flavonoids Min Zhang et al Discussed the effect of ultra-fine grinding technology on the physical and chemical properties and antioxidant activity of Lycium barbarum polysaccharides in Ningxia They found that the weight and solubility of particles are the key factors of antioxidant activity of polymers Ultra-fine grinding technology can reduce the weight, height and size of polysaccharide particles and improve the anti gasification activity Li Ya et al Investigated the effect of ultra micro pulverization technology on the extraction rate of main chemical components of Astragalus The results showed that the extraction rate of astragaloside was 1.57 times, total saponin was 1.62 times, astragalus polysaccharide was 1.35 times, and the extraction rate of extract was 1.27 times, which significantly improved the extraction rate of main effective components of Astragalus Zhang Honggang et al Listed seven kinds of traditional Chinese medicine such as grape seed, Houttuynia cordata and rhubarb through a large number of experimental documents and materials Compared with the effect of ultra micro comminution technology and common comminution technology on the extraction rate of traditional Chinese medicine, the conclusion shows that the content of effective ingredients has been significantly improved after the ultra micro comminution technology is used If this technology can be widely used in the extraction of traditional Chinese medicine, it will bring new things to the production and application of traditional Chinese medicine The vitality of TCM industry has become a new growth point 2 Improve the utilization rate of traditional Chinese medicine and effectively protect the resources of traditional Chinese medicine For the high fiber content of traditional Chinese medicine, such as Astragalus, it is easy to waste resources by using traditional grinding methods If ultra-fine grinding is used, it can effectively reduce the loss of effective ingredients in the production process It is reported that the medicine can be saved by 30% - 70% in general The dosage of pill powder can be reduced to 1 / 3-1 / 5 of the original, while that of decoction is only 1 / 5-1 / 20 of the original Li Decheng et al Studied the application of superfine comminution technology in traditional Chinese medicine preparation and found that the dosage of Jinguishenqi pill after superfine comminution was reduced from the original 3G / pill to 0.9g/pill, and the effect was significant It is very important to protect the resources of traditional Chinese medicine to reduce the waste of traditional Chinese medicine and save the cost of traditional Chinese medicine 3 Promote drug absorption, improve bioavailability and enhance efficacy The application of ultra-fine comminution technology in traditional Chinese medicine mainly refers to the cell level ultra-fine comminution for the purpose of biological cell wall breaking The effective components of the medicine are exposed directly Due to the increase of specific surface area, the contact area between the medicine and the gastrointestinal mucosa is increased, which is more easily absorbed by the gastrointestinal mucosa and gradually absorbed, so as to greatly improve the release speed and absorption degree in the body, as well as the growth Material utilization 4 Safety and health, convenient for clinical application Health requirements is an important link in the comminution process of traditional Chinese medicine, which is easy to be ignored The traditional comminution method is poorly sealed and easy to produce pollution Modern ultra micro pulverization is generally carried out in a totally enclosed dust-free system, which can effectively avoid external pollution; meanwhile, in the process of wall breaking pulverization of traditional Chinese medicine raw materials, it can also kill insect eggs of the same size as the cells of traditional Chinese medicine, reduce the pollution of diseases and insect pests of traditional Chinese medicine, effectively control the microbial indexes and dust of products, ensure the integrity, sex and safety of raw materials, and enable the production of raw materials The products are easier to meet the requirements of GMP The ultra-fine powder of traditional Chinese medicine is fine, with good uniformity of particle size and color, which is convenient for further use and preparation