The role of bioactive peptides in biological skin care products

With the development of biology, especially molecular biology technology, it has brought a new development opportunity to the cosmetic industry Skin care products have developed from fine chemical beauty, plant beauty to biological beauty and gene beauty As the main component of biological skin care products, most of the bioactive polypeptides are cell growth factors They have very small content in vivo, but very high bioactivity They play a biological regulatory role in a variety of cell physiological functions and metabolic activities, directly affect the growth, division, differentiation, proliferation and migration of various types of cells They are used in beauty skin care, plastic surgery, burn ulcer and various kinds of Skin diseases play an important role in wound repair and healing 1 Biological effects of bioactive polypeptides: all kinds of bioactive polypeptides added to beauty skin care products are combined with specific receptors existing on the target cells to play a role The main biological effects are: chemotaxis induce inflammatory cells, stimulate the proliferation and differentiation of the target cells, promote the synthesis and secretion of extracellular matrix such as collagen by the target cells Bioactive peptides play an important role in embryo development, tissue regeneration and wound healing, not only in promoting cell division and differentiation, but also in the synthesis and secretion of bioactive substances, immune response, and even in the inhibition of cell growth In recent years, it has been found that they can directly bind to the specific receptor on the surface of epithelial cell membrane to stimulate the migration and mitosis of vascular epithelium, and also indirectly promote the replication and chemotaxis of endothelial cells and induce the proliferation of blood vessels through the secretion of active substances mediated by macrophages Bioactive peptides can regulate the formation, development and metabolism of T cells, B cells, tissue cells, Langerhans cells and dermal dendrites, and affect their migration and growth rate At the same time, it also stimulates connective tissue, keratinocytes, fibroblasts and macrophages to secrete cytokines, lymphokines, serum proteins, lymphokines, serum proteins, extracellular proteins and matrix polysaccharides In embryonic development, the active polypeptides participate in the regulation of the formation of tissues and organs by regulating the activities of the same or different types of cells; for the mature tissues and organs, the organ damage and function weakening caused by trauma, or the cell viability weakening and aging caused by the lack of growth promoting polypeptides, the active polypeptides have significant repair and reconstruction functions 2 Up to now, there are dozens of bioactive polypeptides related to skin, many of which have been added to beauty skin care products The main ones closely related to beauty skin care and skin soft tissue damage and repair are: fibroblast growth factor (FGF): including acid (aFGF) and basic (bFGF) Acidic fibroblast growth factor (aFGF), a member of fibroblast growth factor (FGF) family, is a multi-functional cell growth factor, which has nutritional, mitogenic and differentiation effects on various mesoderm derived cells There are aFGF receptors in epithelial cells, dermal cells, fibroblasts, vascular endothelial cells, nerve cells, myoblasts, osteoblasts and so on The multi-functional cytokines from mesoderm and neuroectoderm are mitogens with strong function They have mitogenic effect on vascular endothelial cells, fibroblasts, myoblasts, osteoblasts and so on Through their chemotaxis and cell migration, megaphagocytes, mesenchymal cells, endothelial cells, fibroblasts and so on gather to the wound site and start trauma Healing process: repair peptide directly acts on the damaged cell tissues, can promote the growth of fibroblasts, promote the division and proliferation of collagen cells and keratinocytes, quickly repair the deep damaged skin tissues, accelerate the wound healing, and all kinds of wounds to the skin tissues (including skin burns and abrasions caused by ultraviolet rays, acne, peeling, redness and fruit acid after skin replacement) The repair of deep skin damage after cutting has outstanding effect At the same time, the bioactive peptide (aFGF) plays an important role in delaying skin aging, providing skin nutrients, promoting skin cell regeneration and eliminating skin wrinkles In addition, bioactive peptides can also regulate cell secretion, effectively provide nutrition for the body, improve the body immunity, supplement the skin nutrient supply, automatically release and activate the human defense system, inhibit the generation of melanin, control oil secretion when the skin is stimulated by external stimulation, and play an important role in maintaining the normal state of skin cells and skin vitality Clinical trials have proved that aFGF can make skin white and red, moisturize and luster, and reduce wrinkles The comprehensive evaluation of its beauty effect is more than 92%, and the comprehensive evaluation of its effect of removing spots, acne, enhancing skin elasticity and repairing damaged skin is more than 93% This product has the characteristics of high stability, strong activity in human skin environment (pH 5.8), 100% affinity with human skin and so on Compared with bFGF, it can play a more efficient and lasting comprehensive beauty care effect, and its high-tech content makes it the most competitive biological beauty product today 3 The skin care mechanism of bioactive peptides can delay skin aging: skin aging is the external manifestation of human aging, which is the result of the combined effect of endogenous and exogenous factors With the growth of age, the aging of the skin is more and more obvious, mainly manifested as dry, rough, wrinkled, lusterless, inelastic, pale, flabby skin, even skin atrophy, wrinkle and age spots Sunlight or other environmental factors can also cause skin aging and damage, reducing skin cell activity The aging of skin not only affects the appearance and image of human body, but also seriously hinders the physiological function of human skin, and even causes serious pathological changes of skin Bioactive polypeptide is the best active component in skin care It can control or regulate the process of skin aging, protect the damaged skin and delay skin aging It is of great significance to maintain the structure and function of normal skin and maintain the normal physiological activities and metabolism of the body In the form of small particles or through special delivery systems (liposomes, encapsulated liposomes and microspheres), bioactive peptides can be added to cream, essence or emulsion, which can play an important molecular biological effect on aging skin The functions of bioactive peptides are as follows: (1) on the epidermis level, they affect the activity and growth of keratinocytes, activate the migration and epithelialization of keratinocytes, stimulate the differentiation and regeneration of epidermal cells, strongly promote the repair and healing of epidermis, and inhibit the formation of scars（ 2) At the dermal level, it can stimulate the activity of fibroblasts, enhance the structure of extracellular matrix, provide skin nutrients, promote skin wound healing and functional regeneration（ 3) On the overall level of skin: enhance the resistance to environmental damage, ultraviolet radiation, pollutants, irritants, sensitizers, and inflammatory substances, consolidate and enhance skin tension, increase skin elasticity, promote scar tissue decline, reduce scar formation, and delay skin aging The main mechanisms are as follows: (1) promote the proliferation, division and differentiation of epidermal and dermal cells, increase the number of new cells by 20, thicken the skin, and gradually restore the normal structure and physiological function of the skin（ 2) Promote the formation of collagen fiber, reticular fiber and elastic fiber, regulate the formation of collagen and mucopolysaccharide, maintain the balance of water content and electrolyte metabolism in skin tissue, improve the water shortage state of dry skin and moisten skin tissue; (3) promote the formation of new capillaries in skin tissue through the effect on vascular endothelial cells 4 Current clinical application prospect of aFGF in medicine: at present, the clinical application prospect of aFGF is mainly used for wound healing AFGF can promote the recovery and reconstruction of blood vessels in the damaged area, restore and reconstruct the tissue function of the damaged area, enhance the anti infection ability of the damaged area, improve the strength and elasticity of the damaged area after healing, reduce the formation of scars, and significantly shorten the time of wound healing AFGF can be used in burn, surgical trauma, refractory body surface ulcer, oral mucosal erosion and other diseases Application prospects in beauty: aFGF can balance the distribution of pigment, improve the skin color and make the skin smooth and ruddy; accelerate the repair of skin trauma after various cosmetic and plastic operations; smooth wrinkles and moisturize, increase skin elasticity, which has a huge potential market in the beauty industry Add a certain amount of acidic fibroblast growth factor (aFGF) to the beauty skin care products, which can supplement the necessary nutrients of skin cells at any time, maintain the exuberant vitality of skin cells, maintain the elasticity and luster of skin cells, resist skin aging, balance the secretion state of skin cells, and inhibit the formation of acne So it is a great leap to improve the function of skin care products Wuhan Jiu Sheng Tang is committed to developing, producing and selling facial mask and other skin care products, which are rich in bioactive peptides Inspiring in the cosmetics field, it can also show itself and satisfy the hearts of millions of women.