The results of the selection of the top ten research progress in China's hematology in 2021 were announced at the 2nd China Hematology Development Conference

From January 14th to 16th, 2022, the 2nd China Hematology Development Conference will be held online
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With the theme of "Strengthening the Foundation, Emphasizing Clinical Practice, Promoting Transformation - Building a New Ecology of Hematology Innovation and Development", many experts and colleagues in the field of hematology gathered together to exchange the latest progress of hematology and discuss the future development direction
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The meeting selected the top ten research progress of Chinese hematology in 2021, which was announced by Professor Peng Jun, deputy dean of the Institute of Advanced Medicine of Shandong University
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1 Single-cell analysis of the relationship between hematopoietic stem cell heterogeneity and the pathogenesis and treatment of myeloproliferative tumors The Shi Lihong team, Zhang Lei team, Cheng Tao team and Wang Dong team from Southern Medical University revealed the MPN Pathogenesis is associated with HSC lineage bias, and HSC heterogeneity affects MPN disease treatment
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This study is the first to correlate the heterogeneity of hematopoietic stem cells with the pathogenesis and treatment of hematological tumors, revealing the possibility of combining anti-inflammatory drugs to improve the existing treatment methods; research on the pathogenesis, treatment, and recurrence of hematological tumors and even solid tumors has Important revelation
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Link to the paper: https://doi.
org/10.
1016/j.
stem.
2021.
01.
0182 Revealing a new path for the extramedullary development of innate lymphocytes University of Science and Technology of China Tian Zhigang, Peng Hui, Sun Rui and Marseille University Eric Vivier The differentiation potential and regulatory mechanism of adult hepatic hematopoietic precursor cells into hepatic ILC1 (ie, liver resident NK cells) were discovered
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This study revealed a new pathway for the extramedullary development of innate lymphocytes, and provided a theoretical basis for explaining the causes of innate immune dominance in the liver
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Link to the paper: https:// A new mechanism for RNA editing to regulate hematopoietic stem cell differentiation The Jia team collaborated to map the RNA editing map and its dynamic changes of the mouse hematopoietic lineage for the first time, and revealed the new mechanism of Azin1, a new hematopoietic regulator, and its RNA editing coordinated with DDX1 to regulate hematopoietic stem cell differentiation
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This study enriched the mammalian cell RNA editing database and revealed a new mechanism by which RNA editing regulates hematopoietic lineage differentiation
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Link to the paper: https://doi.
org/10.
1182/blood.
20210113144 Uncovering the heterogeneity of adult bone marrow megakaryocytes Wang Qianfei's team from the Institute of Genomics, Chinese Academy of Sciences and Zhou Jiaxi's team from the Institute of Hematology, Chinese Academy of Medical Sciences have made a breakthrough in adulthood The technical bottleneck of bone marrow hyperploid megakaryocytes, the single-cell transcriptome map of adult mouse and adult bone marrow megakaryocytes was drawn, the heterogeneity and differentiation rules of adult bone marrow megakaryocytes were analyzed, and immune subgroups of megakaryocytes were identified
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This study revealed the functions of immune megakaryocytes and provided an important reference for studying the subpopulation composition and functional changes of megakaryocytes under disease conditions
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Link to the paper: https://doi.
org/10.
1182/blood.
20210106975 Single-cell precision analysis of the embryonic origin and specialization law of human innate lymphocytes Lan Yu's team and Wen Aiqing's team of Army Medical University mapped out the transcriptome panorama of the differentiation of human hematopoietic stem progenitor cells into the innate lymphocyte (ILC) lineage, the specialization and maturation of different ILC subsets, and the differentiation of key progenitor cells and precursor cells.
characteristic
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This study revealed the developmental pathway and molecular basis of early human ILCs, and provided theoretical support for lymphocyte regeneration strategies in vitro
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Link to the paper: https://doi.
org/10.
1038/s41422-021-00467-z6 The regulation and mechanism of RNAm6A modification in the blood system Zhang Haojian's team from Wuhan University drew a map of m6A modification in the blood system and analyzed its changes; elucidated the maintenance of IGF2BP2 The role and mechanism of hematopoietic stem cell function
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This study revealed a new mechanism for the maintenance of hematopoietic stem cell function, and laid a theoretical foundation for in-depth exploration of the epitranscriptional regulation mechanism of blood ecology under physiological and pathological conditions
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Link to the paper: https://doi.
org/10.
1016/j.
stem.
2021.
09.
0147 Donor-derived CD7 CAR-T is effective in the treatment of refractory and relapsed T-lineage leukemia with controllable toxicity Chinese Academy of Medical Sciences Hospital of Hematology/Institute of Hematology Feng Xiaoming's team, Beijing Boren Hospital Pan Jing's team, and Shanghai Yake Biotechnology Co.
, Ltd.
Zhang Hongsheng's team are the first to report completely the phase I clinical data of donor-derived CD7 CAR-T in the treatment of refractory and relapsed T-ALL
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This study shows that the use of donor-derived CD7 CAR-T in the treatment of T-ALL can achieve a high complete remission rate (90%), and the overall safety is controllable
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Paper link: 10.
1200/JCO.
21.
00389 Journal of Clinical Oncology 39, no.
30 (October 20, 2021) 3340-3351.
8 Discovery of super-enhancer and its downstream driver gene XBP1s to maintain leukemia stem cell stemness and survival Sun Yat-sen University Pan Jingxuan's team and Jinan University Jin Yanli's team found that the super-enhancer and the XBP1s gene driven by it are an important mechanism to maintain the self-renewal and survival of leukemia stem cells, and are a new drug target for targeting and eradicating leukemia stem cells
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This study provides a new strategy for overcoming tyrosine kinase inhibitor resistance in patients with chronic myeloid leukemia, and also improves people's understanding of the epigenetic regulation of leukemia stem cells
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Link to the paper: https:// Exploring the treatment options for light chain amyloidosis The Li Jian team of Peking Union Medical College Hospital found that compared with chemotherapy alone, doxycycline combined with chemotherapy did not It did not improve progression-free survival, organ remission and overall survival in light chain myocardial amyloidosis
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This study is the first randomized controlled study in related fields in China, which changes the existing treatment path for light chain myocardial amyloidosis
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Paper link: https://doi.
org/10.
1161/CIRCULATIONAHA.
121.
05595310 A series of studies on the treatment of relapsed/refractory multiple myeloma (RRMM) with fully human anti-BCMA CAR (CT103A) Wuhan Tongji Hospital Zhou Jianfeng team and Chinese Academy of Medical Sciences Qiu Lugui's team from Hematology Hospital/Institute of Hematology carried out a series of studies on CT103A in the treatment of RRMM
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The results show that CT103A has good efficacy and safety, and non-human CAR exposure can also benefit, providing important guidance for the management of adverse reactions after CAR-T
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Paper link: https://doi.
org/10.
1182/blood.
2020008936 Summary meeting At the end of the meeting, Professor Cheng Tao, Dean of the Institute of Hematology Hospital/Institute of Hematology, Chinese Academy of Medical Sciences made a final summary
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He said that the research level in the field of hematology has been improving year by year, and the top ten research progresses in China's hematology in 2021 are more cutting-edge, and it also reflects the close combination of basic and clinical.
The results are presented to you
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