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Researchers at Indiana University School of Medicine are developing new ways to investigate why an antibiotic causes hair cell death and permanent hearing loss
in people.
In a recent study published in the journal Developmental Cell, the researchers explained how they identified the autophagy pathway in hair cells linked
to permanent hearing loss caused by aminoglycoside antibiotics.
Dr.
Ototoxicity — drug-induced hearing loss — is one of the leading causes of
hearing loss in humans.
For nearly a century, aminoglycosides have been used to treat serious infections
.
Zhao's lab studies the molecular mechanisms of hearing loss, and he uses biochemical screening to identify proteins
found in hair cells.
Professor Zhao said: "Since aminoglycosides specifically trigger rapid localization changes of RIPOR2 in hair cells, we hypothesize that RIPOR2 is essential in aminoglycoside-induced hair cell death
.
The researchers developed a model in the lab that had normal hearing but significantly reduced
RIPOR2 expression.
"We then found that RIPOR2 regulates the autophagy pathway
of hair cells.
The study's authors say the protein found in this study could be used as a drug target in future studies to prevent aminoglycosides-induced hearing loss
.
In addition to Zhao and Li, the authors of this article include Chang Liu, a postdoctoral fellow in the Zhao Laboratory, and Dr.
Journal Reference:
Jinan Li, Chang Liu, Ulrich Mü ller, Bo Zhao.
