The researchers found that new immunosuppressive cells affect the anti-tumor immune response

chinese and foreign researchers recently found that a new immunosuppressive cell affects the anti-tumor immune response, thus affecting the effectiveness of immunotherapy in some tumor patients. The findings have been published online in nature medicine, an authoritative international academic journal.
according to Professor Zhu Bo of oncology department of Xinqiao Hospital, in recent years, the immunotherapy of tumors represented by PD-1/PD-L1 antibodies has made a major breakthrough and become one of the important methods of clinical tumor treatment. However, in clinical practice, the effective rate of PD-1/PD-L1 antibody treatment of tumors is only 20%-30%, which in addition to the tumor cells can continue to evolve to evade immune identification, tumor patients can also produce a variety of immune-inhibited cells, such as myelin source suppression cells, affecting the effect of immunotherapy.
scientists have been trying to find other immunosuppressive cells in tumor patients. Recently, Professor Zhu Bo's team, in cooperation with Chinese and foreign scientific research institutions, found a new type of immunosuppressive cell from the pregenesome cell source of red line in the spleen, liver and exosome blood of tumor patients, which inhibits CD8-T cell-mediated immune response by producing reactive oxygen (ROS), resulting in a decrease in antiviral/bacterial and anti-tumor immune response function in tumor patients.
It is understood that normal red precursor cells should have differentiated into normal red blood cells, but Professor Zhu Bo's team found that this cell, not only can not be normal differentiation, but also produced a very strong immunosuppressive ability, so that normal immune cells can not effectively kill tumor cells and remove invading pathogens in the body. This study provides a new way to further understand the mechanism of tumor immunosuppression and improve the efficacy of immunotherapy in tumor patients. (Source: Xinhua News Agency, Li Song Zengli)