The research team of the national edible bacteria center's medicinal resources made progress in the study of durian skin

"Mechanism of intestinal flora and proteomics in regulationing immune function of Durio Zibethinus rind polysaccharide" was recently published in the journal Oxidative And Cellular Longevity (IF:5.834) in the journal JCR 2 of the Chinese Academy of Sciences.
the study was supported by the Digestive Micro-Ecological Pharmacology Innovation Unit of the Chinese Academy of Medical Sciences and the Medical and Health Science and Technology Innovation Project of the Chinese Academy of Medical Sciences (2019-I2M-5-055).
durian is the fruit of the evergreen durian durian of wood cotton, with a fruity sweetening temperature and anti-inflammatory activity.
durian skin is the peel of durian, the current research is mainly for surface chemical action and adsorption function, but the research on its functional activity is relatively small.
, polysaccharides, as biomolecules, play an important role in regulating the intestinal bacteriologic group, treating constipation, immunomodulation and so on.
similar findings in the early stages of the laboratory's study of durian polysaccharides, which have the effect of enhancing the body's immunity, regulating the intestinal bacteria, optimizing the intestinal environment, and improving constipation symptoms.
, this paper has carried out a detailed and in-depth study on the efficacy of durian peel polysaccharine to enhance the body's immunity.
study used cyclophosphamide (CTX) to build immunosuppressive mouse models and evaluate the effects of durian polysaccharides on immune function in immunosuppressed mice through proteomics and intestinal bacterial studies.
results showed that the high dose group (200 mg/kg) of durian peel polysaccharine significantly improved thymus and spleen index and improved spleen tissue structure compared to the model group α; TNF-α content; increased acidic phosphatase (ACP), lactic acid dehydrogenase (LDH), superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) vitality; increased the activity of hydrogen peroxide enzyme (CAT) in the liver, reduced the content of acetaldehyde (MDA) and enhanced immune activity in immunosuppressive model mice.
proteomics studies have shown that the dosing group can significantly increase the expression of low-affinity immunoglobulin Fc-Fc-FC-FC-iii, signal converter, and transcription activator 1 (STAT1) compared to the model group, participating in the regulation of metabolic pathways such as Autoimmune thyroid disease, Staphylococcus aureus and NF-B signaling pathway.
of intestinal microbes showed increased levels of SCFAs in the dosage group compared to the model group, increased relative abundance of the beneficial bacteria Akkermansia, Bacteroides, Paraprevotella, and decreased relative abundance in Ruminococcus and Oscillospira.
results show that durian polysaccharides can have a beneficial effect on immunomodulation by regulating protein expression and improving bacterial composition.
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