The research group of Wang Yi from Zhejiang University School of Pharmacy reported the flavonoids in Rhodiola rosea in Advanced Science...

<>On January 14 ,2022 , Professor Wang Yi's research group from the State Key Laboratory of Component Traditional Chinese Medicine, Zhejiang University School of Pharmacy, Zhejiang University Interdisciplinary Innovation Center published a research titled " Discovery of Herbacetin as a Novel SGK1 Inhibitor to Alleviate Myocardial Hypertrophy" in Advanced Science Papers, and recommended as the current cover paper .

Rhodiola rosea, such as Rhodiola rosea and Rhodiola rosea, have a long history of medicinal use in China and Europe.

The research team first proved in the whole animal model that Rhodiola rosea extract can significantly inhibit cardiac hypertrophy and improve cardiac function, and comprehensively used gene expression profiling and Connectivity Map ( cMap ) methods to find serum / glucocorticoid-induced kinase 1 ( SGK1 ) ) is its potential target; then a new technology for evaluating SGK1 activity based on mass spectrometry-responsive probes was constructed, and a class of flavonoids with Herbacetin as the parent nucleus was screened from Rhodiola rosea extracts with good The inhibitory activity of SGK1 was confirmed by protein thermal transfer assay and KINOMEscan ? in vitro enzyme binding assay.

Figure 1.

Professor Wang Yi's research group has long been engaged in the research on the pharmacodynamic substances of traditional Chinese medicine, and is committed to using multidisciplinary methods to construct a new technology for evaluating the efficacy of traditional Chinese medicine, and to screen and discover the active components / ingredients of traditional Chinese medicine on a multi-scale model ( Anal Chem , 2020 ; Chem Comm , 2020 ; Pharmacol Res , 2019 )

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