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The remission rate is 17.3% higher than that of monotherapy!

 Last Update: 2021-10-01
 Source: Internet
 Author: User

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Article source: Medical Rubik's Cube Info

Author: Shi Bei

On September 16, Amgen announced the first positive results of the first combination therapy in the Phase Ib/II CodeBreaK 101 study of patients with advanced colorectal cancer (CRC) with KRAS G12C mutation

The objective response rate (ORR) of the 26 patients included in the efficacy analysis set (including 5 patients who progressed after receiving sotorasib monotherapy) was 27%

This dose exploration and dose expansion cohort study enrolled 31 patients with KRAS G12C mutation metastatic CRC who had received extensive pretreatment (median 2 front-line therapy; range 1-10)

In addition to reporting on the Lumakras combination therapy study, Amgen today also reached a collaboration with Boehringer Ingelheim (BI) to jointly explore the potential synergistic effects of the combination of Boehringer Ingelheim SOS1::pan-KRAS inhibitor BI 1701963 and Lumakras

BI 1701963 is an oral small molecule under research that can bind to the catalytic domain of SOS1, prevent its interaction with inactive KRAS, reduce the production of active KRAS, and thereby inhibit the MAPK signaling pathway in KRAS-dependent tumors

So far, Amgen has deployed the world's most comprehensive clinical development project for the KRAS G12C mutation

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