The team of Professor Ming Kuang from the Center of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital of Sun Yat-sen University and Professor Lin Shuibin from the Translational Medicine Research Center successfully confirmed the new function of tRNA m7G modification to regulate tumor progression in tumors, and revealed the previously unreported tRNA for the first time The m7G modification has a molecular correlation with tumorigenesis and development
The 5-year survival rate of intrahepatic cholangiocarcinoma is only 5%-40%, and 70% of patients with intrahepatic cholangiocarcinoma are at an advanced stage when they are first diagnosed, and treatment options are limited
Based on the new tRNA modification sequencing technology independently developed by Lin Shuibin’s team, it broke through the technical bottleneck of tRNA sequencing research and successfully confirmed the new function of tRNA m7G modification to regulate tumor progression in tumors, providing a new mechanism for tumor mRNA translation abnormalities Explain, and then provide new ideas and new targets for the targeted therapy of intrahepatic cholangiocarcinoma (ICC) in addition to gene mutation and gene transcription abnormality, which has important reference significance for the drug development and precise intervention of advanced ICC
Kuang Ming’s team took "RNA modification to regulate tumor translation" as a breakthrough.
In terms of mechanism, by combining tRNA reduction and splicing sequencing, ribosomal nascent peptide chain complex sequencing and ribosomal sequencing, the researchers further discovered that 22 tRNAs in ICC contained m7G modifications and were decoded by m7G tRNA codon frequency bias , Selectively regulates the translation of a variety of related oncogenes including EGFR signaling and cell cycle
This study reported for the first time the key regulatory role of tRNA m7G modification in tumors, and clarified the molecular mechanism of tRNA m7G modification to selectively regulate the translation of oncogenes, laying a solid theoretical foundation for targeted intervention in the progress of abnormal tumor translation suppression ICC
Related paper information: https://doi.
https://doi.
org/10.
1016/j.
molcel.
2021.
07.
003
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