The regulatory effect of febrile temperatures on the key molecules in the migration of immune cells

On December 3, 2019, Chen Jianfeng, researcher of Molecular Cell Science Innovation Center / Institute of Biochemistry and cell biology, Chinese Academy of Sciences, was invited to publish a review paper entitled regulation of immune cell traffic by fabric temperatures in International Journal of Hypertermia, which systematically summarized fabric The regulation of temperature on the key molecules in the process of immune cell migration was discussed The application of temperature in the regulation of immune cell migration in autoimmune diseases and tumors was also discussed Homing of immune cells is the key link of immunity and host defense It plays an important role in effective immune monitoring and maintaining the homeostasis of internal environment Integrins, which are expressed on the surface of immune cells, are the core molecules that regulate the homing of immune cells Chen Jianfeng's research group has long been devoted to the analysis of the function regulation of integrin by extracellular microenvironment and its function in the tissue-specific migration of immune cells, and has made a series of achievements in the regulation of integrin by chemokines, metal ions and temperature (immunity 2019, J cell biol 2018, PLoS Biol 2018, Dev cell 2014, PNAs 2010, PNAs 2006, NAT struct Biol 2003) Recent research results have revealed the molecular mechanism of fever promoting immune cell migration through the heat shock protein 90 (Hsp90) - α 4 integrin heat sensing signal pathway, as well as the important function of this mechanism in immune regulation (immunity 2019), which has attracted international attention Febrile temperatures are body temperatures that are outside the normal range, usually caused by hyperthermia or fever In recent 20 years, it has been found that febrile temperatures can act on a variety of adhesion molecules on the surface of immune cells or vascular endothelial cells to comprehensively regulate the adhesion and migration of immune cells First, high temperature passes through gp130 linked IL-6 / sIL-6R α trans signaling Pathway specifically enhanced the localization and rolling adhesion of L-selectin-dependent immune cells in the inner wall of blood vessels; secondly, the hsp90-alpha4 integrin signal axis, as a thermosensitive pathway, promoted the directional migration of T-lymphocytes and other alpha4 integrin positive immune cells; and then, high temperature selectively increased CCL21 (CC chemokine) The density of ligand 21) and intercellular adhesion molecule-1 (ICAM-1) enhanced the function of α L β 2 integrin Among them, the expression of ICAM-1 induced by high temperature is also realized by IL-6 trans signaling pathway To sum up, fabric temperatures systematically regulate the functions of different adhesion molecules in the process of immune cell migration, so as to promote the migration of immune cells to secondary lymphoid organs or inflammatory sites, enhance the immune response, and achieve the maintenance of immune monitoring and immune homeostasis.