The reason of prolonged disintegration time of tablet press
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Last Update: 2013-05-08
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Source: Internet
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Author: User
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The disintegration time of tablet press is prolonged If the disintegration time of oral tablet is prolonged, the dissolution rate of the drug from the tablet press mixture is slow, and the effective blood concentration cannot be reached within the appropriate time, so the bioavailability of the tablet will be reduced During the formulation design, the problem of prolonged disintegration time can be solved by adding disintegrating agent, changing the type of adhesive or reducing the concentration of adhesive During tablet pressing, when the mixing time of lubricant and other particles is prolonged, the binding force between particles will be weakened and the hardness of tablets will be reduced In order to ensure the hardness of tablets, the pressure of tablet press should be increased However, the increase of compression pressure makes the porosity and pore diameter of the tablet smaller, which is not conducive to the disintegration of the tablet and prolongs the disintegration time of the tablet During granulation, hard particles are produced due to excessive wetting during liquid spraying, forming hard flakes, and the disintegration time is also prolonged.
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