The rate of cancerchange of benign tumors in the intestines accelerates? It's cancer-suppressing genes that have changed.

DOI: 10.15252/embj.2019102771researchers using RNAScop in situ hybridization (in situ hybridization, ISH) and found that Nedd4 is mainly expressed in the hidden stem cell area, while Nedd4l is evenly distributed in the hidden fluff axis, two gene expression enzyme proteins - neuronal pre-cell progenitor stoym NEDD4) and homologous protein NEDD4L can inhibit the Wnt pathway, which plays an important role in cell growth and assayafternedd4 and Nedd4l deficiencies promote intestinal resusanding, the researchers removed the Nedd4 and Nedd4l genes in mice and intestinal organs and found that the long-term deletion of both genes promoted the proliferation of intestinal stem cells (the intestinal stem cells, ISCs) and crypts(crypt) and, in addition, removed the nedd4 and Ned4l tumors in benign tumorsNEDD4/NEDD4L-mediated Wnt pathway regulation mechanismmechanism, NEDD4 and NEDD4L are targeted to LGR5 receptors and DVL2, protease and lysosome degradation, thus negatively regulating the Wnt/beta-catenin signalLead author Laura Novellasdemunt notes that understanding the effects of the absence of these two genes on tumors, and its importance in cancer evolution, could help further explore new therapies that slow tumor development, such as blocking the Wnt pathwayreferences:two genes snr slow down development of theof the intestinal tumors, nEDD4 and NEDD4L regulate wnt signalling and intestinal cell cell priming by degrading LGR5original title: EMBO J: How to suppress benign cancer of the intestine? Scientists discover two key cancer-suppressing genes!