The Production Process of tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate

The production process of tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate is a multi-step process that involves several chemical reactions and purification steps.
The starting materials and the intermediate products are synthesized in various reaction vessels, such as reactors, condensers, and separators, using different chemical reactions, such as condensation, substitution, and reduction reactions.
The final product is then isolated and purified using various purification techniques, such as recrystallization and chromatography.

The production process can be divided into several stages, each of which involves specific chemical reactions and purification steps.
The following is a detailed description of the production process of tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate.

Stage 1: Synthesis of 2-amino-4,6-dimethyl-5-oxo-4,5-dihydro-1H-pyrazole
The first step in the production process of tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate is the synthesis of 2-amino-4,6-dimethyl-5-oxo-4,5-dihydro-1H-pyrazole, which is a key intermediate.
This compound can be synthesized by following a well-known chemical reaction, such as the Gattermann-Reischauer reaction or the Peterson reaction.

Stage 2: Synthesis of 2-(2,6-dimethyl phenyl) acetaldehyde
In this stage, 2-amino-4,6-dimethyl-5-oxo-4,5-dihydro-1H-pyrazole is transformed into 2-(2,6-dimethyl phenyl) acetaldehyde, which is another key intermediate.
This transformation can be achieved by using a well-known chemical reaction such as the Wilkinson reaction.

Stage 3: Synthesis of 4-chloro-3-(2,6-dimethylphenyl)butyronitrile
In this stage, 2-(2,6-dimethyl phenyl) acetaldehyde is transformed into 4-chloro-3-(2,6-dimethylphenyl)butyronitrile, which is an intermediate compound.
This transformation can be achieved by using a well-known chemical reaction such as the Heck reaction.

Stage 4: Synthesis of tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate
The final stage in the production process of tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate involves the synthesis of the final product.
This compound can be synthesized by using a well-known chemical reaction, such as the Stille reaction, in which the intermediate compound 4-chloro-3-(2,6-dimethylphenyl)butyronitrile is transformed into tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate, using tosyl chloride as a reagent.

Purification Stage:
After the final product is synthesized, it is necessary to purify it to obtain a pure sample.
This can be achieved using various techniques, such as recrystallization and chromatography.

Recrystallization:
Recrystallization is a common purification technique that involves dissolving the compound in a suitable solvent and then allowing the solvent to evaporate, leaving behind pure crystals.
The crystals can then be collected and washed with a suitable solvent to remove any impurities.

Chromatography:
Chromatography is another common purification technique that involves separating the compound from other components using a