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Technetium 99m (Tc-99m) is a commonly used radioisotope in medical imaging and it is produced by the reaction of molybdenum-99 (Mo-99) with technetium-99m pertechnetate (TcO4-) in the production process known as the Tc-99m Generator.
Technetium-99m is a short-lived isotope with a half-life of about 6.
7 hours and it decays into rhenium-187 (Re-187) and technetium-99 (Tc-99) which is still radioactive.
The production process of Tc-99m starts with the irradiation of natural moissanite (89Zr + n → 93Mo + 2.
17 MeV) in a nuclear reactor to produce molybdenum-99.
The Mo-99 is then purified and stored in a generator, typically made of stainless steel or titanium, until it is needed for use in medical imaging.
The generator is designed to separate the Tc-99m from the Mo-99 by passing aolybdene solution through the generator.
The aolybdene solution is composed of ammonium molybdate and hydrochloric acid and it is used to dissolve the Mo-99 and form Tc-99m.
The Tc-99m generator is typically composed of an anode and a cathode, with anolyte solution being circulated through the anode and cathode.
The anode is made of a material that is not reactive with Tc-99m and is typically made of stainless steel or titanium, while the cathode is made of a material that is reactive with Tc-99m, typically a noble metal such as platinum.
The Tc-99m pertechnetate is formed at the cathode by the reaction of Tc-99 with the aolybdene solution and it is then continuously removed from the generator by a vacuum pump.
The Tc-99m generator is typically used for medical imaging for several weeks before it needs to be reloaded with new Mo-99.
The generator is then emptied and cleaned, and the process is repeated.
It's important to note that the Tc-99m generator should be handled by trained personnel and must be operated in accordance with the manufacturer's instructions.
In summary, the production process of Tc-99m involves the irradiation of natural moissanite in a nuclear reactor to produce molybdenum-99, which is then purified and stored in a Tc-99m generator.
The generator is designed to separate Tc-99m from the Mo-99 by passing an aolybdene solution through the generator, where the Mo-99 is dissolved and form Tc-99m and other radioisotopes.
The Tc-99m generator is typically composed of an anode and a cathode, with the anode made of a material that is not reactive with Tc-99m and circulates the aolybdene solution and the cathode made of a material that is reactive with Tc-99m.
The Tc-99m generator is typically used for medical imaging for several weeks before it needs to be reloaded with new Mo-99.