The Production Process of (αS)-α-Amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid

(αS)-α-Amino-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid, also known as DMF, is a versatile organic compound that is widely used as a solvent, a reagent, and a building block in the chemical industry.
The production process of DMF involves several steps, including the synthesis of the precursor molecule, its subsequent conversion to DMF, and the purification of the final product.

Synthesis of Precursor Molecule

The synthesis of the precursor molecule for DMF production involves several steps.
The first step is the synthesis of 3,4-dihydro-2H-pyrimidine-2,5-dione, which is also known as 2,5-bis(2,4-dioxo-3-oxazolidinyl)pyrimidine.
This molecule is synthesized from 2,4-dioxo-3-oxazolidinyl)pyrimidine and acetaldehyde in the presence of a strong acid catalyst.

The next step is the oxidation of the 2,5-bis(2,4-dioxo-3-oxazolidinyl)pyrimidine molecule to form 2,5-bis(2,4-dioxo-3-oxazolidinyl)pyridine.
This is achieved by treating the 2,5-bis(2,4-dioxo-3-oxazolidinyl)pyrimidine with sodium periodate in an aqueous solution.

Conversion to DMF

Once the precursor molecule has been synthesized, it is converted to DMF through a series of chemical reactions.
The first step is the reaction of the 2,5-bis(2,4-dioxo-3-oxazolidinyl)pyridine molecule with a strong acid, such as sulfuric acid, to form the corresponding 2,5-bis(2,4-dioxo-3-oxazolidinyl)pyridine sulfate salt.

The next step is the hydrolysis of the 2,5-bis(2,4-dioxo-3-oxazolidinyl)pyridine sulfate salt in the presence of water to form DMF.
This is achieved by treating the salt with water at a high temperature, such as 100-150°C.

Purification of DMF

After the DMF has been produced through the conversion of the precursor molecule, it must be purified to remove any impurities that may have been introduced during the synthesis and conversion steps.
This is typically done through a series of chemical reactions and chromatography techniques.

The purification process typically involves the following steps:

1. Neutralization: DMF is neutralized with a strong base, such as sodium hydroxide, to remove any remaining acid groups.
   
2. Extraction: The neutralized DMF is then extracted with a solvent, such as ether or benzene, to remove any impurities that may have been introduced during the neutralization step.
   
3. Distillation: The extracted DMF is then distilled to remove any remaining impurities and to purify the DMF to a high degree of purity.
   
4. Crystallization: Finally, the purified DMF is crystallized to produce a pure, single-crystal form of the compound that is suitable for use in the chemical industry.
   

Overall Production Process

The overall production process for DMF involves the synthesis of the precursor molecule, its conversion to DMF, and the purification of the final product.
The synthesis of the precursor molecule involves several steps, while the conversion of the precursor molecule to DMF involves several chemical reactions that must be carefully controlled to ensure the