The Production Process of Quetiapine fumarate

Quetiapine fumarate is a psychotropic drug that is used to treat conditions such as schizophrenia, bipolar disorder, and major depressive disorder.
The production process of quetiapine fumarate involves several steps, including the synthesis of the active ingredient and the formation of the fumarate salt.

The synthesis of quetiapine starts with the reaction of a substituted phenylamine with a substituted malonate in the presence of a strong acid catalyst.
This reaction results in the formation of a substituted 1,2-dihydroquinoline, which is a key intermediate in the synthesis of quetiapine.

The next step in the synthesis of quetiapine is the reaction of the 1,2-dihydroquinoline intermediate with a substituted benzaldehyde in the presence of a condensing agent such as dicyclohexylcarbodiimide (DCC).
This reaction results in the formation of a substituted 1,2-dihydroquinoline-6,7-dione, which is a key intermediate in the synthesis of quetiapine.

The next step in the synthesis of quetiapine is the reduction of the 1,2-dihydroquinoline-6,7-dione intermediate using a reducing agent such as lithium aluminum hydride (LiAlH4).
This reaction results in the formation of the final product, quetiapine.

The formation of the fumarate salt of quetiapine involves the reaction of quetiapine with fumaric acid in the presence of a neutralizing agent such as sodium hydroxide.
This reaction results in the formation of quetiapine fumarate, which is the final product.

The production process of quetiapine fumarate involves several steps, including the synthesis of the active ingredient and the formation of the fumarate salt.
The synthesis of quetiapine starts with the reaction of a substituted phenylamine with a substituted malonate in the presence of a strong acid catalyst.
This reaction results in the formation of a substituted 1,2-dihydroquinoline, which is a key intermediate in the synthesis of quetiapine.