The Production Process of Propanamide, N-(6-chloro-3-pyridazinyl)-

Propanamide is an important intermediate chemical used in the production of various pharmaceuticals and agrochemicals.
It is also known as Meta-Chlorphenamide or MCP.
The production process of Propanamide involves several steps, which are carried out in a chemical plant.

The first step in the production process is the synthesis of 3-pyridazinic acid.
This is done by reacting anhydrous ammonia and chlorphenol in the presence of an acid catalyst.
The reaction produces 3-chlorpyridazine, which is then hydrolyzed to yield 3-pyridazinic acid.

The next step is the nitration of 3-pyridazinic acid, which involves treating the acid with nitrating acid, typically nitric acid.
This reaction produces N-(3-nitro-1H-pyridazyl)-3-pyridazinic acid, which is also known as NAPA (Nitro-3-acetyl-pyridine-2,6-dicarboxylic acid).

The NAPA is then reduced to yield Propanamide.
This is done by treating the NAPA with hydrogen in the presence of a catalyst such as palladium on barium sulfate.
The reaction produces Propanamide, which is also known as N-(6-chloro-3-pyridazinyl)-2,6-dimethyl-4-oxo-4H-pyran-3-ylideneamide.

The Propanamide produced in the previous step is then purified by crystallization.
The purified Propanamide is then used as an intermediate in the production of various pharmaceuticals and agrochemicals.

One of the major advantages of the production process of Propanamide is that it is highly efficient and yields a high purity product.
This is achieved through the use of advanced chemical processing equipment and the implementation of strict quality control measures.

The production process of Propanamide also has a number of safety considerations.
The use of hazardous chemicals such as nitric acid requires careful handling and disposal.
The chemical plant must also have appropriate safety measures in place to protect workers from potential hazards.

In conclusion, the production process of Propanamide involves several steps, including the synthesis of 3-pyridazinic acid, nitration, reduction, and purification.
The process is highly efficient and yields a high purity product, and is carried out in a chemical plant using advanced chemical processing equipment and strict quality control measures.
The production of Propanamide also requires careful handling and disposal of hazardous chemicals and appropriate safety measures to protect workers.