The Production Process of N-Tosyl-5-bromo-4,7-diazaindole

The production process of N-Tosyl-5-bromo-4,7-diazaindole is a multi-step synthesis that involves several chemical reactions.
The following is an overview of the production process of N-Tosyl-5-bromo-4,7-diazaindole, which is widely used as a chemical intermediate in the production of various pharmaceuticals, agrochemicals, and other chemical products.

Step 1: Preparation of Tosyl-5-bromo-4,7-diazaindole
The first step in the production of N-Tosyl-5-bromo-4,7-diazaindole is the preparation of Tosyl-5-bromo-4,7-diazaindole.
To prepare Tosyl-5-bromo-4,7-diazaindole, 5-bromo-4,7-diazaindole is first reacted with tosyl chloride in the presence of a solvent such as DMF.
The reaction is exothermic, and the mixture is stirred for several hours at room temperature.
The resulting mixture is then poured into water, and the resulting solid is collected by filtration and dried to obtain Tosyl-5-bromo-4,7-diazaindole.

Step 2: Reduction of Tosyl-5-bromo-4,7-diazaindole
The next step in the production of N-Tosyl-5-bromo-4,7-diazaindole is the reduction of Tosyl-5-bromo-4,7-diazaindole to obtain N-Tosyl-5-bromo-4,7-diazaindole.
To reduce Tosyl-5-bromo-4,7-diazaindole, the solid is suspended in a solvent such as sodium hydroxide solution, and the mixture is stirred for several hours at room temperature.
The resulting mixture is then neutralized with hydrochloric acid, and the resulting solid is collected by filtration and dried to obtain N-Tosyl-5-bromo-4,7-diazaindole.

Step 3: Purification of N-Tosyl-5-bromo-4,7-diazaindole
The final step in the production of N-Tosyl-5-bromo-4,7-diazaindole is the purification of the obtained N-Tosyl-5-bromo-4,7-diazaindole.
To purify N-Tosyl-5-bromo-4,7-diazaindole, the solid is suspended in a solvent such as ethyl acetate, and the mixture is stirred for several hours at room temperature.
The resulting mixture is then filtered to obtain a solution of N-Tosyl-5-bromo-4,7-diazaindole in ethyl acetate.
The solution is then washed with water, and the resulting solution is dried over anhydrous sodium sulfate.
The solvent is then removed under vacuum, and the resulting solid is collected by filtration and dried to obtain pure N-Tosyl-5-bromo-4,7-diazaindole.

In conclusion, the production process of N-Tosyl-5-bromo-4,7-diazaindole involves several chemical reactions, including the preparation of Tosyl-5-bromo-4,7-diazaindole, its reduction to obtain N-Tosyl-5-bromo-4,7-diazaindole, and its purification to obtain pure N-Tosyl-5-bromo-4,7-diazaindole.
The purified N-Tosyl-5-bromo-4,7-diazaindole is widely used as a chemical intermediate in the production of various pharmaceuticals, agrochemicals, and other chemical products.
The production process of N-Tosyl-5-bromo-4,7-diazaindole is a complex multi-step synthesis that requires careful planning, execution, and monitoring to ensure the