The Production Process of Methyl 3-[[(2-methoxy-2-oxoethyl)amino]sulfonyl]-2-thiophenecarboxylate

The Production Process of Methyl 3-[[(2-methoxy-2-oxoethyl)amino]sulfonyl]-2-thiophenecarboxylate in the Chemical Industry

Methyl 3-[[(2-methoxy-2-oxoethyl)amino]sulfonyl]-2-thiophenecarboxylate is an important intermediate in the production of various chemicals and pharmaceuticals.
This compound is widely used in the production of certain types of pesticides, herbicides, and fungicides.
The production process of this compound involves several steps, which are discussed in detail below.

Step 1: Preparation of 2-methoxy-2-oxoethanol
The production of Methyl 3-[[(2-methoxy-2-oxoethyl)amino]sulfonyl]-2-thiophenecarboxylate begins with the preparation of 2-methoxy-2-oxoethanol.
This compound is synthesized by the reaction of ethylene oxide with sodium methoxide in the presence of water.
The reaction is exothermic and requires careful control to avoid excessive heating.

Step 2: Addition of ammonia to 2-methoxy-2-oxoethanol
Next, ammonia is added to 2-methoxy-2-oxoethanol to form 2-methoxy-2-oxoethylamine.
This reaction is carried out in the presence of a strong acid catalyst, such as sulfuric acid, and at a moderate temperature.
The reaction produces a solution of 2-methoxy-2-oxoethylamine in water, which is then extracted with an organic solvent, such as ethyl acetate.

Step 3: Sulfonation of 2-methoxy-2-oxoethylamine
To prepare Methyl 3-[[(2-methoxy-2-oxoethyl)amino]sulfonyl]-2-thiophenecarboxylate, 2-methoxy-2-oxoethylamine is sulfonated with sulfuric acid.
The reaction produces a solution of the sulfonated derivative in water, which is then treated with charcoal to remove any remaining impurities.

Step 4: Reaction with thiophenecarboxylic acid
The sulfonated derivative is then reacted with thiophenecarboxylic acid to produce Methyl 3-[[(2-methoxy-2-oxoethyl)amino]sulfonyl]-2-thiophenecarboxylate.
This reaction is carried out in the presence of a strong acid catalyst, such as sulfuric acid, and at a moderate temperature.
The reaction produces a solution of the desired compound in water, which is then extracted with an organic solvent, such as ethyl acetate.

Step 5: Purification of the product
The purification of Methyl 3-[[(2-methoxy-2-oxoethyl)amino]sulfonyl]-2-thiophenecarboxylate involves several steps, including filtration, extraction, and chromatography.
The filtrate is extracted with an organic solvent, such as ether, and the organic phase is then purified by chromatography on a silica gel column.
The resulting pure compound is then dried and packaged for shipment.

Conclusion
The production of Methyl 3-[[(2-methoxy-2-oxoethyl)amino]sulfonyl]-2-thiophenecarboxyl