The Production Process of IMIDAZO[1,2-B]PYRIDAZINE-6-CARBOXYLIC ACID MONOHYDROCHLORIDE

IMIDAZO[1,2-B]PYRIDAZINE-6-CARBOXYLIC ACID MONOHYDROCHLORIDE is an important intermediate chemical used in the production of various pharmaceuticals, agrochemicals, and other chemical products.
The production process of IMIDAZO[1,2-B]PYRIDAZINE-6-CARBOXYLIC ACID MONOHYDROCHLORIDE involves several steps, which will be discussed in detail in this article.

Step 1: Preparation of raw materials

The production of IMIDAZO[1,2-B]PYRIDAZINE-6-CARBOXYLIC ACID MONOHYDROCHLORIDE begins with the preparation of raw materials.
The key raw material for the production of this chemical is 2,6-dimethylpyridine, which is obtained by the hydropyridination of 2-methyl-6-nitropyridine.
Other raw materials used in the production process include imidazole, hydrochloric acid, and water.

Step 2: Hydrolysis of 2,6-dimethylpyridine

The next step in the production process is the hydrolysis of 2,6-dimethylpyridine.
This involves the cleavage of the N-C bond in 2,6-dimethylpyridine to give 2,6-dimethylpyridine-N-oxide.
The hydrolysis reaction is carried out in the presence of water and a strong acid catalyst, such as sulfuric acid.

Step 3: Coupling of imidazole and 2,6-dimethylpyridine-N-oxide

The next step involves the coupling of imidazole and 2,6-dimethylpyridine-N-oxide to form IMIDAZO[1,2-B]PYRIDAZINE-6-CARBOXYLIC ACID MONOHYDROCHLORIDE.
This coupling reaction is carried out in the presence of a strong acid catalyst, such as sulfuric acid, and a solvent, such as toluene or xylene.
The reaction conditions, including the temperature and pressure, are carefully controlled to ensure the formation of the desired product.

Step 4: Hydrochloration of IMIDAZO[1,2-B]PYRIDAZINE-6-CARBOXYLIC ACID MONOHYDROCHLORIDE

The final step in the production process is the hydrochloration of IMIDAZO[1,2-B]PYRIDAZINE-6-CARBOXYLIC ACID MONOHYDROCHLORIDE.
This involves the addition of hydrogen chloride gas to the solution of IMIDAZO[1,2-B]PYRIDAZINE-6-CARBOXYLIC ACID MONOHYDROCHLORIDE in a solvent, such as acetonitrile or dichloromethane.
The reaction is typically carried out under conditions of high temperature and pressure, and the formation of the desired product is monitored by TLC or HPLC analysis.

Quality control measures

The production process of IMIDAZO[1,2-B]PYRIDAZINE-6-CARBOXYLIC ACID MONOHYDROCHLORIDE is highly controlled to ensure the production of a high-quality product.
Quality control measures are typically carried out at each step of the production process, including the purification and characterization of the intermediate products.
The final product is subjected to rigorous quality control tests, including TLC or HPLC analysis, melting point determination, and elemental analysis, to ensure its purity and conformity to the required specifications.

Conclusion

The production