The Production Process of ethyl4-amino-2-methylquinoline-6-carboxylate

Ethyl 4-amino-2-methylquinoline-6-carboxylate is a compound commonly used in the pharmaceutical industry as an intermediate in the production of certain drugs.
The production process of this compound involves several steps, which are generally carried out in a laboratory or industrial setting.
In this article, we will go over the production process of ethyl 4-amino-2-methylquinoline-6-carboxylate in detail.

Step 1: Synthesis of Ethyl 4-Amino-2-methylquinoline-6-carboxylate
The synthesis of ethyl 4-amino-2-methylquinoline-6-carboxylate typically involves several steps.
The first step is the synthesis of ethyl 4-amino-2-methylquinoline-6-carboxylate nitrile, which is then hydrolyzed to produce the carboxylate.
The synthesis of the nitrile can be carried out using various methods, such as the Koenigs-Knorr reaction or the P2P process.

Step 2: Hydrolysis of Ethyl 4-Amino-2-methylquinoline-6-carboxylate Nitrile
The ethyl 4-amino-2-methylquinoline-6-carboxylate nitrile is hydrolyzed using a strong acid, such as hydrochloric acid, in the presence of a solvent, such as ethyl acetate.
The hydrolysis reaction is carried out at a temperature of around 50-60°C for several hours.
The resulting product is then filtered and washed with water to remove any excess acid.

Step 3: Purification of Ethyl 4-Amino-2-methylquinoline-6-carboxylate
The resulting product from the hydrolysis step is then purified using several techniques, such as recrystallization, chromatography, and distillation.
Recrystallization is a process in which the impure compound is dissolved in a solvent, such as ethanol or water, and allowed to cool slowly.
The resulting crystals are then collected, washed with a solvent, and dried to remove any impurities.

Chromatography is a technique that involves passing the impure compound through a column packed with a solid adsorbent, such as silica gel or alumina.
The compound is then eluted with a solvent, such as ethyl acetate or methanol, and collected in separate fractions.
The fractions containing the desired compound are then collected and concentrated to produce a pure sample.

Distillation is a process in which the impure compound is heated and the resulting vapor is condensed back into a liquid form.
The resulting liquid is then collected and repeated until the desired purity is achieved.

Overall, the production process of ethyl 4-amino-2-methylquinoline-6-carboxylate involves several steps, including the synthesis of the nitrile, hydrolysis, purification, and isolation.
These steps are generally carried out in a laboratory or industrial setting using various chemical reactions and techniques.
The purity of the resulting compound is crucial in the production of certain drugs, and thus, the purification process is a critical step in the production process of ethyl 4-amino-2-methylquinoline-6-carboxylate.