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Ethyl-4-methyl pyrimidine-5-carboxylate, also known as EPMCA, is an important intermediate in the synthesis of various chemicals and pharmaceuticals.
The production process of EPMCA involves several steps, which are carried out in a chemical plant equipped with the necessary equipment and facilities.
The first step in the production of EPMCA is the synthesis of 4-methyl-pyrimidine-5-carboxylic acid.
This is typically carried out by a two-step reaction process, in which methyl iodide is reacted with 5-bromopyrimidine-2,4-dione to produce 5-bromomethyl-2,4-diaminopyrimidine.
This intermediate is then hydrolyzed to produce 4-methyl-pyrimidine-5-carboxylic acid.
The next step in the production of EPMCA is the carboxylation of 4-methyl-pyrimidine-5-carboxylic acid.
This is typically carried out using a carboxylation reactor, which is equipped with a catalyst, such as iron or copper, to accelerate the reaction.
The carboxylation reaction involves the addition of carbon monoxide and hydrogen gas to 4-methyl-pyrimidine-5-carboxylic acid, under high pressure and temperature conditions.
This results in the formation of EPMCA, which is then isolated and purified from the reaction mixture.
The purification of EPMCA is typically carried out using a combination of crystallization, distillation, and chromatography techniques.
This is necessary to remove any impurities that may be present in the product, and to produce a pure and homogeneous material.
Once the EPMCA has been purified, it is typically converted into other chemicals or pharmaceuticals through a series of chemical reactions.
This may involve the modification of the molecule, such as the addition of other functional groups, or the formation of polymers or complexes.
The exact nature of these reactions will depend on the intended use of the EPMCA, and may involve the use of various chemical reagents and catalysts.
In conclusion, the production process of EPMCA involves several steps, which are carried out in a chemical plant equipped with the necessary equipment and facilities.
The first step is the synthesis of 4-methyl-pyrimidine-5-carboxylic acid, which is then carboxylated to produce EPMCA.
The purification of EPMCA is then carried out using a combination of crystallization, distillation, and chromatography techniques, before being converted into other chemicals or pharmaceuticals through a series of chemical reactions.
