The Production Process of Dovitinib

Dovitinib is a phosphatidylinositol 3-kinase inhibitor, commonly used in cancer treatment.
The production process of Dovitinib involves several steps, including synthesis of the starting material, chemical reactions, and purification of the final product.
In this article, we will take a detailed look at the production process of Dovitinib.

Synthesis of Starting Material
The starting material for the production of Dovitinib is a compound called 2-(4-(4-((4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl)-3,5-difluorophenyl)-2H-1,2,4-triazol-3-yl)benzamide.
This compound is synthesized through several steps, including the synthesis of the intermediate compound 2,4-difluorophenyl-3,5-difluorotriazole.
The synthesis of this intermediate compound involves the reaction of 2,4-difluorophenylzinc chloride with 3,5-difluorotriazole in the presence of a solvent such as THF.
The synthesis of the starting material involves several additional steps, including the reaction of 2-(4-((4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl)-3,5-difluorophenyl)acetamide with sodium hydride and subsequent treatment with a carboxylic acid.

Chemical Reactions
The next step in the production process of Dovitinib is the formation of the final compound through a series of chemical reactions.
The synthesized starting material is subjected to several chemical reactions, including hydrogenation, nitro group reduction, and formylation.
The hydrogenation step involves the addition of hydrogen atoms to the nitro group of the starting material, which is followed by reduction of the nitro group to an amino group.
The formylation step involves the addition of a carbon monoxide molecule to the starting material, which results in the formation of the final compound.

Purification of the Final Product
Once the final compound has been formed, it is necessary to purify it to obtain a pure sample.
This step involves the use of chromatography techniques, such as high-pressure liquid chromatography (HPLC).
In HPLC, the final compound is passed through a column filled with a stationary phase, and the compound is separated based on its chemical properties, such as size and charge.
The pure compound is then collected and dried, and the process is repeated until a pure sample of Dovitinib is obtained.

Overall, the production process of Dovitinib involves several steps, including the synthesis of the starting material, chemical reactions, and purification of the final product.
The process requires the use of various chemical reagents and equipment, such as solvents, reflux condensers, and chromatography columns.
The quality of the final product is crucial for its effectiveness in cancer treatment, making the purification process a critical step in the production process.