The Production Process of Defluoro Aprepitant

Defluorapatit 200 is a drug used to prevent nausea and vomiting associated with cancer chemotherapy.
It is a synthetic substance produced through a complex chemical process that involves several steps.
The production process of Defluorapatit 200 involves several stages, including the synthesis of the basic compound, its purification, and the final formulation of the drug.

Step 1: Synthesis of the basic compound
The synthesis of the basic compound of Defluorapatit 200 starts with the reaction of the precursor compound, known as loxapine.
Loxapine is a benzoxazepine derivative that is first synthesized through a series of chemical reactions involving the synthesis of intermediate compounds.
The reaction is carried out in stoichiometric proportions using inorganic and organic compounds such as hydrogen chloride, sodium hydroxide, triethylamine, and benzaldehyde.

Step 2: Purification of the basic compound
After the synthesis of the basic compound, it is essential to purify it to remove any impurities that may have been introduced during the reaction.
The purification process involves several techniques such as crystallization, chromatography, and recrystallization.
The goal of these techniques is to obtain a pure sample of the basic compound that can be used in the next stage of the production process.

Step 3: Condensation reaction
The next step in the production process of Defluorapatit 200 is the condensation reaction.
In this reaction, the basic compound obtained from the previous step is reacted with another compound known as 1,2-dichloro-4-nitrobenzene.
The reaction is carried out in the presence of a condensing agent such as dicyclohexylcarbodiimide.
The condensation reaction results in the formation of a new compound, which is then purified to remove any impurities.

Step 4: Hydrolysis
The final step in the production process of Defluorapatit 200 is hydrolysis.
In this step, the compound obtained from the condensation reaction is treated with a strong acid such as hydrochloric acid.
The reaction results in the cleavage of the compound into two fragments, which are then separated using chromatography.
The final product is a pure sample of Defluorapatit 200, which is ready for formulation into the final drug product.

In conclusion, the production process of Defluorapatit 200 is a complex chemical process that involves several stages, including the synthesis of the basic compound, its purification, and the final formulation of the drug.
The process requires the use of various chemical reactions, purification techniques, and equipment to ensure the production of a safe and effective drug product.
The purification process is critical to the removal of impurities that may have been introduced during the reaction, and the final step of hydrolysis is necessary for the formation of the final product.
Overall, the production process of Defluorapatit 200 is a highly regulated and controlled process that must meet strict quality and safety standards before the final product can be released to the market.