The Production Process of Cyclopropyl-(2,4-dichloro-pyrimidin-5-ylmethyl)-amine

The production process of cyclopropyl-(2,4-dichloro-pyrimidin-5-ylmethyl)-amine, commonly known as Lenvatinib, is a complex and multi-step process that involves several chemical reactions and purification steps.
Lenvatinib is a drug used to treat various types of cancer, including renal cell carcinoma, hepatocellular carcinoma, and non-small cell lung cancer.

The production process of Lenvatinib can be divided into the following stages:

1. Synthesis of the starting material
2. Purification of the starting material
3. Reaction of the starting material to form the intermediate
4. Purification of the intermediate
5. Reaction of the intermediate to form the final product

6. Purification of the final product

   
   

7. Synthesis of the starting material:

   
   

The starting material for the production of Lenvatinib is 2,4-dichloro-pyrimidine-5-carbaldehyde, which is synthesized by a multi-step reaction process involving the reaction of various reagents and chemicals.
The synthesis of the starting material is a critical step in the production process as it determines the quality and purity of the final product.

2. Purification of the starting material:

After the synthesis of the starting material, it is essential to purify it to remove any impurities that may affect the quality of the final product.
This purification step is usually done by chromatography, which involves separating the starting material based on its chemical properties.

3. Reaction of the starting material to form the intermediate:

The purified starting material is then subjected to a chemical reaction that converts it into the intermediate, cyclopropyl-2,4-dichloro-pyrimidine-5-carboxamide.
This reaction is usually carried out in the presence of a solvent and a catalyst, and is followed by purification to remove any impurities.

4. Purification of the intermediate:

The purified intermediate is then subjected to a series of chemical reactions and purification steps to reduce its impurities.
This includes the reduction of the intermediate to form cyclopropyl-2,4-dichloro-pyrimidine-5-amine, followed by purification to remove any remaining impurities.

5. Reaction of the intermediate to form the final product:

The purified cyclopropyl-2,4-dichloro-pyrimidine-5-amine is then subjected to a final reaction that converts it into Lenvatinib.
This reaction is usually carried out in the presence of a solvent and a catalyst, and involves the formation of the final product through a series of chemical reactions.

6. Purification of the final product:

The final product is then purified to remove any impurities that may have been introduced during the reaction steps.
This purification step is usually done by chromatography, which involves separating the final product based on its chemical properties.

Overall, the production process of Lenvatinib is a complex and multi-step process that requires strict quality control at every stage.
The success of the production process depends on the purity of the starting material, the efficiency of the reaction steps, and the purity of the final product.
The production of Lenvatinib is an important process in the treatment of cancer, and continuous research and development are being conducted to improve the production process and reduce its cost.