The Production Process of Benzoic acid, 4-amino-, 2-(dimethylamino)ethyl ester

The production process of benzoic acid, 4-amino-, 2-(dimethylamino)ethyl ester, a synthetic chemical compound, involves several steps that involve various chemical reactions and purification techniques.
The final product is a white or off-white crystalline solid with a melting point of 230-233°C.

The production process of benzoic acid, 4-amino-, 2-(dimethylamino)ethyl ester can be broken down into the following steps:

Step 1: Preparation of reactants
The preparation of the reactants involves the synthesis of 4-amino-2-(dimethylamino)ethanol and benzoic acid.
4-amino-2-(dimethylamino)ethanol is synthesized by condensing dimethylamine and formaldehyde, followed by hydrolysis of the resulting dimethylformamide.
Benzoic acid can be synthesized by several methods, including the oxidation of benzil or the reaction of benzaldehyde with sodium hydroxide.

Step 2: Esterification
The esterification step involves the reaction of 4-amino-2-(dimethylamino)ethanol and benzoic acid to form the corresponding ester.
This reaction is usually carried out in the presence of a polar or protic solvent, such as ethanol or methanol, and a catalyst, such as sodium hydroxide or hydrochloric acid.
The reaction typically proceeds under conditions of high temperature and pressure, with the reaction mixture being stirred or agitated to ensure a uniform reaction.

Step 3: Purification
The product of the esterification step is typically impure and may contain residual reactants, unreacted starting materials, and undesirable side products.
To ensure the purity of the final product, the reaction mixture is subjected to several purification steps, including precipitation, filtration, and chromatography.

Precipitation involves the addition of a suitable reagent, such as hot water or aqueous sodium hydroxide, to the reaction mixture to form a precipitate.
The precipitate is then filtered and washed with a suitable solvent, such as ethanol or methanol, to remove any impurities.

Filtration involves the use of a filter paper or a filter cloth to separate the solid precipitate from the liquid phase.
The filtered solid is then washed with a suitable solvent to remove any residual impurities.

Chromatography involves the separation of the desired product from other components of the reaction mixture by using a suitable stationary phase, such as silica gel or alumina, and a suitable mobile phase, such as a mixture of solvents or a gas.
The stationary phase is typically packed into a column, and the reaction mixture is passed through the column, allowing the components to be separated based on their interactions with the stationary phase.

Step 4: Recrystallization
The purified product is typically in the form of a liquid or a solid that contains impurities, such as solvent residues or undesirable side products.
To obtain a pure crystalline product, the liquid or solid is subjected to a recrystallization step, which involves dissolving the impure product in a suitable solvent and allowing it to crystallize out of solution.
The solvent is typically removed by evaporation, and the resulting crystals are then washed with a suitable solvent to remove any impurities.

The final product of the production process of benzoic acid, 4-amino-, 2-(dimethylamino)ethyl ester is a white or off-white crystalline solid with a melting point of 230-233°C.
The purity of the final product can be determined by spectroscopic techniques, such as infrared spectroscopy or nuclear magnetic resonance spectroscopy.

In conclusion, the production process of benzoic acid, 4-amino-, 2-(dimethylamino)ethyl ester involves several steps that involve the synthesis of reactants, esterification, purification, and recrystallization.
The final product is a synthetic chemical compound with a wide range of