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    Home > Active Ingredient News > Drugs Articles > The Production Process of Benzamidine, hydrochloride

    The Production Process of Benzamidine, hydrochloride

    • Last Update: 2023-04-26
    • Source: Internet
    • Author: User
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    Benzamidine hydrochloride is a organic compound that is commonly used as a intermediate in the production of various chemicals and pharmaceuticals.
    The production process of benzamidine hydrochloride involves several steps, including the synthesis of benzamidine and its subsequent hydrochlorination.


    1. Synthesis of Benzamidine:
      The synthesis of benzamidine involves the reaction of benzaldehyde and ammonia in the presence of a strong acid catalyst, such as sulfuric acid.
      The reaction results in the formation of benzamidine, which is then isolated and purified through a series of steps, such as washing, filtration, and recrystallization.
    2. Hydrochlorination of Benzamidine:
      The hydrochlorination of benzamidine involves the addition of hydrogen chloride gas to benzamidine in the presence of a Lewis acid catalyst, such as ferric chloride.
      The reaction results in the formation of benzamidine hydrochloride, which is then isolated and purified through a series of steps, such as washing, filtration, and recrystallization.
    3. Purification of Benzamidine Hydrochloride:
      The purification process of benzamidine hydrochloride involves several steps, including washing, filtration, and recrystallization.
      These steps are done to remove any impurities that may have formed during the synthesis and hydrochlorination process.
    4. Characterization of Benzamidine Hydrochloride:
      The chemical properties of benzamidine hydrochloride can be determined through various techniques such as spectroscopy, chromatography, and spectroscopic methods like NMR and IR.

    Benzamidine hydrochloride is a colorless or white crystalline solid with a strong, unpleasant odor.
    It is soluble in water, ethanol, methanol, and other organic solvents.
    The melting point and boiling point of benzamidine hydrochloride can vary depending on the manufacturing process.


    Benzamidine hydrochloride is commonly used in the production of various chemicals and pharmaceuticals, such as antihistamines, anti-allergic agents, and antidepressants.


    In conclusion, the production process of benzamidine hydrochloride involves the synthesis of benzamidine, its hydrochlorination, and purification.
    The purification process is done to remove any impurities that may have formed during the synthesis and hydrochlorination process.
    The chemical properties of benzamidine hydrochloride can be determined through various techniques such as spectroscopy, chromatography, and spectroscopic methods like NMR and IR.
    The final product is a colorless or white crystalline solid with a strong, unpleasant odor, soluble in water, ethanol, methanol and other organic solvents.
    It is commonly used in the production of various chemicals and pharmaceuticals.


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