The Production Process of ACETIC ACID 2-CYANO-PYRIDIN-3-YLMETHYL ESTER

Acetic acid 2-cyano-pyridin-3-ylmethyl ester, also known as CNP-ACETIC ACID, is a organic compound widely used as a reagent in chemical synthesis and pharmaceutical research.
The production process of CNP-ACETIC ACID involves several steps, including the synthesis of the starting materials, the esterification reaction, and the purification and isolation of the final product.

The synthesis of the starting materials, 2-cyano-pyridine-3-amide and methyl acetate, is typically carried out through either a condensation reaction or an alkylation reaction.
The condensation reaction involves the application of heat, pressure, and a condensing agent, such as calcium oxide or phosphorus trisulfide, to a mixture of the starting materials in the presence of a solvent, such as acetonitrile or DMF.
The alkylation reaction, on the other hand, involves the addition of the methyl group to the 2-cyano-pyridine-3-amide molecule using a strong base, such as sodium hydride, and a polar protic solvent, such as ethanol or acetic acid.

Once the starting materials have been synthesized, the esterification reaction can be performed by heating the mixture of the two compounds in the presence of a condensing agent, such as sulfuric acid or phosphoric acid.
The reaction typically takes place at a temperature of around 150-180°C and is monitored by TLC or HPLC to ensure that the reaction is complete.

After the esterification reaction has been completed, the mixture is typically cooled to room temperature and the organic phase is separated from the aqueous phase using a separating funnel.
The organic phase is then dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to remove any remaining solvent.

The final step in the production process of CNP-ACETIC ACID is the purification and isolation of the product.
This is typically carried out using a combination of column chromatography and recrystallization.
The crude product is applied to a column packed with an inert solid support, such as silica gel or alumina, and eluted with a solvent that separates the desired product from any impurities.
The pure product is then collected and recrystallized using a suitable solvent, such as ethanol or acetonitrile, to obtain a pure sample of CNP-ACETIC ACID.

In conclusion, the production process of CNP-ACETIC ACID is a multi-step process that requires the synthesis of the starting materials, the esterification reaction, and the purification and isolation of the final product.
The use of suitable reaction conditions, solvents, and purification methods can ensure the efficient and cost-effective production of this important organic compound.