The Production Process of 7-Isoquinolinecarbonitrile

7-Isoquinolinecarbonitrile is an important organic compound that is widely used in the chemical industry.
It is synthesized through a multi-step process that involves several chemical reactions.
In this article, we will take a closer look at the production process of 7-Isoquinolinecarbonitrile.

Step 1: Bromination of Benzene
The production of 7-Isoquinolinecarbonitrile begins with the bromination of benzene.
In this process, benzene is treated with bromine in the presence of a solvent such as carbon tetrachloride.
The reaction is catalyzed by a metal bromide, and the resulting product is bromobenzene.

Step 2: Chlorination of Benzene
The next step involves the chlorination of bromobenzene.
In this process, bromobenzene is treated with chlorine in the presence of a solvent such as chloroform.
The reaction is catalyzed by a metal chloride, and the resulting product is 4-chlorobenzene.

Step 3: Reduction of Chlorobenzene
4-Chlorobenzene is then reduced to 4-aminobenzene using a reducing agent such as tin chloride in the presence of hydrochloric acid.
The reaction results in the formation of 4-aminobenzene.

Step 4: Nitration of 4-Aminobenzene
4-Aminobenzene is then treated with nitric acid to produce 4-nitrobenzene.
The reaction is typically carried out in the presence of a solvent such as acetic acid.

Step 5: Sulfonation of 4-Nitrobenzene
4-Nitrobenzene is then treated with sulfuric acid to produce 4-nitrobenzenesulfonic acid.
The reaction is typically carried out in the presence of a solvent such as water.

Step 6: Dehydration of 4-Nitrobenzenesulfonic Acid
4-Nitrobenzenesulfonic acid is then treated with anhydrous sodium sulfate to remove water.
The resulting product is 4-nitrobenzenediacid.

Step 7: Coupling of 4-Nitrobenzenediacid and 1,2-Diaminocyclohexane
The final step involves the coupling of 4-nitrobenzenediacid and 1,2-diaminocyclohexane to produce 7-Isoquinolinecarbonitrile.
The reaction is typically carried out in the presence of a solvent such as dimethylformamide.

Overall, the production process of 7-Isoquinolinecarbonitrile involves several chemical reactions that are carried out in a series of stages.
Each step in the process is carefully controlled to ensure the production of a high-quality product.
The resulting 7-Isoquinolinecarbonitrile is then purified and isolated for use in a variety of applications in the chemical industry.