The Production Process of 6-Isoquinolinecarboxaldehyde (9CI)

6-Isoquinolinecarboxaldehyde (9CI) is an important organic compound that is commonly used as a raw material in the production of various chemicals, pharmaceuticals, and other products.
The production process of 9CI involves several steps, including the synthesis of isatin, thealkaline hydrolysis of isatin, and the reduction of the resulting 6-nitro-5,6-dihydroimidazo[1,2-d]isoxazole to 9CI.

The synthesis of isatin is the first step in the production of 9CI.
Isatin is synthesized by the condensation of 2-nitropropane and phenylalanine in the presence of a catalyst.
This reaction is carried out in a nitrogen atmosphere and requires strict control over the temperature and pressure to ensure that the desired product is obtained.
After the synthesis of isatin, it is purified to remove any impurities that may have been introduced during the reaction.

The next step in the production of 9CI is the alkaline hydrolysis of isatin.
This step involves the treatment of isatin with a solution of sodium hydroxide to produce 6-nitro-5,6-dihydroimidazo[1,2-d]isoxazole.
The reaction is carried out in a well-ventilated area, and the mixture is stirred for several hours to ensure that the reaction is complete.
The resulting product is then filtered to remove any solid impurities and the pH is adjusted to around 4.

The final step in the production of 9CI is the reduction of 6-nitro-5,6-dihydroimidazo[1,2-d]isoxazole to produce 9CI.
This step is carried out by treating the 6-nitro-5,6-dihydroimidazo[1,2-d]isoxazole with sodium borohydride in the presence of a solvent such as benzene.
The reaction is carried out in a closed system and requires strict control over the temperature and pressure to ensure that the desired product is obtained.

Once the production of 9CI is complete, the product is purified to remove any impurities that may have been introduced during the reaction.
This purification process involves several steps, including filtration, crystallization, and chromatography.
The purified 9CI is then packaged and shipped to customers.

In conclusion, the production process of 6-Isoquinolinecarboxaldehyde (9CI) involves several steps, including the synthesis of isatin, the alkaline hydrolysis of isatin, and the reduction of the resulting 6-nitro-5,6-dihydroimidazo[1,2-d]isoxazole to 9CI.
The process requires strict control over the temperature and pressure to ensure that the desired product is obtained.
The purification process involves several steps to remove any impurities that may have been introduced during the reaction, and the final product is packaged and shipped to customers.