The Production Process of 6-Chloro-N-(3-methoxypropyl)pyridazin-3-amine

The production process of 6-chloro-N-(3-methoxypropyl)pyridazin-3-amine, also known as Methoxy-6-chloropyridazinamine, is a complex multi-step process that involves several chemical reactions and purification steps.
The final product is an important intermediate in the production of various chemicals and pharmaceuticals.

The production process of 6-chloro-N-(3-methoxypropyl)pyridazin-3-amine can be divided into several stages, including the preparation of the starting materials, the synthesis of the pyridazin-3-amine intermediate, and the chlorination of the intermediate to form the final product.

Preparation of starting materials:
The production of 6-chloro-N-(3-methoxypropyl)pyridazin-3-amine begins with the preparation of the starting materials, which include 3-methoxypropyl chloride and pyridazine-2,6-diamine.

Synthesis of pyridazin-3-amine intermediate:
The next step is the synthesis of the pyridazin-3-amine intermediate, which is prepared by reacting pyridazine-2,6-diamine with para-aminophenol in the presence of a strong acid catalyst, such as sulfuric acid.
This reaction is known as a condensation reaction and produces a condensed ring compound, which is then reduced to form the pyridazin-3-amine intermediate.

Chlorination of pyridazin-3-amine intermediate:
The pyridazin-3-amine intermediate is then chlorinated to form the final product, 6-chloro-N-(3-methoxypropyl)pyridazin-3-amine.
This is typically achieved by treating the intermediate with chlorine gas in the presence of a solvent, such as acetonitrile or dichloromethane.

Purification of the final product:
After the chlorination reaction is complete, the final product is typically purified by several methods, including filtration, crystallization, and chromatography.
These steps are necessary to remove any impurities that may have been introduced during the synthesis and purification process.

Final product storage and handling:
The final product is then stored in a cool, dry place until it is ready for use in the production of other chemicals and pharmaceuticals.
Proper handling and storage of the final product are critical to maintain its chemical stability and prevent degradation or contamination.

Overall, the production process of 6-chloro-N-(3-methoxypropyl)pyridazin-3-amine involves several chemical reactions and purification steps, and requires a high degree of technical expertise and specialized equipment.
The final product is an important intermediate in the production of various chemicals and pharmaceuticals, and its purity and quality play a critical role in the effectiveness and safety of the final products.