The Production Process of 6-CHLORO-IMIDAZO[1,2-A]PYRIDINE-3-CARBONITRILE

The production process of 6-chloro-imidazo[1,2-a]pyridine-3-carbonitrile, also known as 6-CIN, is a complex and multi-step process that involves a variety of chemical reactions and purification techniques.
The process typically involves the following steps:

1. Preparation of the starting materials: The production of 6-CIN typically begins with the synthesis of two key starting materials: 2-chloro-1,3-oxazepine and 1,3-dichloroacetone.
   These starting materials are then purified and characterized to ensure their purity and conformity to the desired specifications.
   
2. Condensation reaction: The purified starting materials are then subjected to a condensation reaction, typically carried out in the presence of a condensation agent such as pyridine, to form a precursor compound known as 1,3-oxazepanecarboxyl chloride.
   
3. Hydrolysis reaction: The precursor compound is then subjected to a hydrolysis reaction, typically carried out in the presence of a solvent such as sodium hydroxide, to generate the intermediate compound 1,3-oxazepin-10-one.
   
4. Reductive nitration: The intermediate compound is then subjected to a reductive nitration reaction, typically carried out in the presence of a reducing agent such as hydrazine and a nitrating agent such as nitric acid, to form the compound 6-chloro-imidazo[1,2-a]pyridin-3-one.
   
5. Dehydrogenation: The compound formed in the reductive nitration reaction is then subjected to a dehydrogenation reaction, typically carried out in the presence of a dehydrogenating agent such as selenium or titanium dioxide, to generate the final compound 6-chloro-imidazo[1,2-a]pyridine-3-carbonitrile (6-CIN).
   
6. Purification: The final compound is then purified and characterized to ensure its purity and conformity to the desired specifications.
   This typically involves a series of techniques such as crystallization, filtration, and chromatography.
   

Overall, the production process of 6-CIN involves a combination of chemical reactions and purification techniques to generate the final product.
The key steps in the process include the synthesis of the starting materials, the condensation and hydrolysis reactions, the reductive nitration reaction, and the dehydrogenation reaction.
The purification and characterization of the final compound are also critical steps to ensure the quality and consistency of the final product.
Due to the complexity of the process, the production of 6-CIN typically requires the expertise of highly trained chemists and the use of sophisticated equipment and techniques to ensure the optimal yield and purity of the final product.