The Production Process of 6-Chloro-5-hydroxy-nicotinic acid methyl ester

The Production Process of 6-Chloro-5-hydroxy-nicotinic acid methyl ester in the Chemical Industry

6-Chloro-5-hydroxy-nicotinic acid methyl ester, also known as 5-chloro-6-hydroxy-nicotinic acid methyl ester or 6-chloro-5-hydroxylaminonic acid methyl ester, is a type of organic compound that is used as an intermediate in the production of various chemicals, drugs, and agrochemicals.
The compound is formed by the reaction of nicotinic acid and chloroform, followed by the conversion of the resulting nicotinic acid methyl ester to the desired compound through a series of chemical reactions.

The production process of 6-chloro-5-hydroxy-nicotinic acid methyl ester typically involves the following steps:

Step 1: Preparation of Nicotinic Acid
The first step in the production of 6-chloro-5-hydroxy-nicotinic acid methyl ester is the preparation of nicotinic acid.
This is typically done by reacting niacin, which is a type of vitamin B3, with hydrochloric acid to form nicotinic acid hydrochloride.
The nicotinic acid hydrochloride is then purified and converted to the required form through a series of chemical reactions.

Step 2: Conversion of Nicotinic Acid to Nicotinic Acid Methyl Ester
The next step in the production of 6-chloro-5-hydroxy-nicotinic acid methyl ester is the conversion of nicotinic acid to nicotinic acid methyl ester.
This is typically done by reacting nicotinic acid with methyl iodide in the presence of a solvent such as ether or hexane.
The resulting nicotinic acid methyl ester is then isolated and purified.

Step 3: Chlorination of Nicotinic Acid Methyl Ester
The next step in the production of 6-chloro-5-hydroxy-nicotinic acid methyl ester is the chlorination of nicotinic acid methyl ester.
This is typically done by reacting the nicotinic acid methyl ester with chloroform in the presence of a catalyst such as zinc chloride.
The resulting 6-chloro-5-hydroxy-nicotinic acid methyl ester is then isolated and purified.

Step 4: Conversion of 6-chloro-5-hydroxy-nicotinic Acid Methyl Ester to the Desired Compound
The final step in the production of 6-chloro-5-hydroxy-nicotinic acid methyl ester is the conversion of the compound to the desired form through a series of chemical reactions.
The specific conversion process will depend on the intended use of the compound, and may involve further reaction with other chemicals, such as amines or alcohols.

Overall, the production process of 6-chloro-5-hydroxy-nicotinic acid methyl ester involves several steps, including the preparation of nicotinic acid, the conversion of nicotinic acid to nicotinic acid methyl ester, the chlorination of nicotinic acid methyl ester, and the conversion of the resulting compound to the desired form.
The purity and quality of the final product will depend on the accuracy and precision of the steps in the production process.