The Production Process of 6-Chloro-4(3H)-quinazolinone

6-Chloro-4(3H)-quinazolinone is an important raw material in the pharmaceutical and chemical industries, and it is widely used as an intermediate in the production of various drugs.
The production process of 6-chloro-4(3H)-quinazolinone can be divided into several stages, including the preparation of raw materials, the generation of intermediates, and the purification of the final product.

The preparation of raw materials is the first step in the production of 6-chloro-4(3H)-quinazolinone.
The raw materials used in the production of 6-chloro-4(3H)-quinazolinone are primarily 4-chloro-3-nitro-aniline and potassium carbonate.
The 4-chloro-3-nitro-aniline used as the raw material must meet certain specifications, such as purity and particle size, to ensure that the final product meets the required standards.
The potassium carbonate is used as a catalyst in the production process, and its particle size and purity must also be carefully controlled.

In the second stage of the production process, the generation of intermediates, the 4-chloro-3-nitro-aniline and potassium carbonate are reacted in a series of reactions to form the intermediate product, quinazoline-4-carboxylic acid.
This reaction is typically carried out in an organic solvent, such as acetone or ethanol, at a moderate temperature.
The intermediate product is then treated with sodium hydroxide to generate the second intermediate, 6-chloro-4-oxo-4,7-dihydroquinazoline-3-carboxylic acid.
This reaction involves the addition of water to the intermediate product, which results in the desired intermediate.

In the final stage of the production process, the purification of the final product, the 6-chloro-4-oxo-4,7-dihydroquinazoline-3-carboxylic acid is treated with sodium carbonate and water to form the final product, 6-chloro-4(3H)-quinazolinone.
This reaction involves the neutralization of the intermediate product with sodium carbonate, followed by treatment with water.
The final product is then typically purified by recrystallization, which involves dissolving the product in a suitable solvent and allowing it to crystallize out.

The production process of 6-chloro-4(3H)-quinazolinone is a well-established and efficient process, and the quality of the final product is carefully monitored and controlled at every stage of the process.
The production process is also highly scalable, which allows for the efficient production of large quantities of the final product.
The production of 6-chloro-4(3H)-quinazolinone is a critical process in the pharmaceutical and chemical industries, and it plays a vital role in the production of various drugs.