The Production Process of 6-CHLORO-4-ETHYL-3-PHENYL-PYRIDAZINE

The production process of 6-chloro-4-ethyl-3-phenyl-pyridazine, also known as 6-CCEPP, is an important process in the chemical industry.
This compound is widely used as a catalyst in the production of various polymers, such as polyethylene and polypropylene.

The production process of 6-CCEPP involves several steps, including the synthesis of the pyridazine precursor, its chlorination, and the final cyclization step.
The process can be broken down into the following phases:

1. Synthesis of the Pyridazine Precursor: The synthesis of the pyridazine precursor involves the reaction of aniline with malonic acid in the presence of a condensation agent such as dicyclohexylcarbodiimide (DCC).
   This reaction results in the formation of a diazo compound, which is then hydrolyzed to form the pyridazine precursor.
   
2. Chlorination of the Pyridazine Precursor: The pyridazine precursor is then chlorinated using chlorine gas or a chlorinating agent such as thionyl chloride.
   This reaction results in the formation of the chlorinated pyridazine precursor.
   
3. Cyclization of the Chlorinated Pyridazine Precursor: The final step in the production of 6-CCEPP is the cyclization of the chlorinated pyridazine precursor.
   This is typically carried out by heating the precursor in the presence of a catalyst, such as sodium hydroxide or a strong acid.
   
4. Purification of the Final Product: After the cyclization reaction, the final product is purified by recrystallization or other appropriate methods.
   This step removes any impurities and results in the formation of pure 6-CCEPP.
   

In conclusion, the production process of 6-CCEPP is a multi-step process that involves the synthesis of the pyridazine precursor, its chlorination, and the final cyclization step.
The use of appropriate catalysts and purification methods is crucial for the production of pure 6-CCEPP, which is widely used as a catalyst in the production of various polymers.