The Production Process of (6-Bromo-pyridin-3-ylmethyl)-isopropyl-amine

The production process of (6-bromo-pyridin-3-ylmethyl)-isopropyl-amine is a multi-step process that involves several chemical reactions and purification steps.
The compound is used in various industrial applications such as pharmaceuticals, agrochemicals, and research chemicals.
In this article, we will discuss the production process of (6-bromo-pyridin-3-ylmethyl)-isopropyl-amine in detail.

Step 1: Preparation of 3-brompyridine
The first step in the production process of (6-bromo-pyridin-3-ylmethyl)-isopropyl-amine is the preparation of 3-brompyridine.
This compound is synthesized by reacting pyridine with hydrobromic acid in the presence of a solvent such as acetonitrile or DMF.
The reaction is exothermic, and it should be carried out with proper safety precautions.
The product is then concentrated under reduced pressure, and the resulting residue is purified by column chromatography using a mixture of ethyl acetate and dichloromethane as the eluent.

Step 2: Preparation of isopropylamine
The next step in the production process of (6-bromo-pyridin-3-ylmethyl)-isopropyl-amine is the preparation of isopropylamine.
This compound is synthesized by reducing isopropyl bromide with lithium aluminum hydride (LiAlH4) in the presence of a solvent such as ether or hexane.
The reaction is exothermic, and it should be carried out with proper safety precautions.
The product is then concentrated under reduced pressure, and the resulting residue is purified by column chromatography using a mixture of ethyl acetate and dichloromethane as the eluent.

Step 3: Preparation of (6-bromo-pyridin-3-ylmethyl)-isopropyl-amine
The final step in the production process of (6-bromo-pyridin-3-ylmethyl)-isopropyl-amine is the synthesis of the compound itself.
This is done by reacting 3-brompyridine and isopropylamine in the presence of a solvent such as toluene or xylene.
The reaction is exothermic, and it should be carried out with proper safety precautions.
The product is then purified by column chromatography using a mixture of ethyl acetate and dichloromethane as the eluent.

Step 4: Purification of (6-bromo-pyridin-3-ylmethyl)-isopropyl-amine
After the synthesis of (6-bromo-pyridin-3-ylmethyl)-isopropyl-amine, the product is purified by column chromatography using a mixture of ethyl acetate and dichloromethane as the eluent.
This step is important to remove any impurities that may have formed during the synthesis steps.

In conclusion, the production process of (6-bromo-pyridin-3-ylmethyl)-isopropyl-amine is a multi-step process that involves several chemical reactions and purification steps.
The compound is used in various industrial applications such as pharmaceuticals, agrochemicals, and research chemicals.
The process is carried out with a series of reaction and purification steps, and it requires a good understanding of the reaction mechanism and the use of proper safety precautions.