The Production Process of 6-[4-Aminophenyl]pyridazin-3(2H)-one

The production process of 6-[4-amino-phenyl]pyridazin-3(2H)-one is an important process in the chemical industry and is widely used in the pharmaceutical, agrochemical, and other industries.
The compound is an important intermediate in the synthesis of various active ingredients and is also used as a reagent in several chemical reactions.
In this article, the production process of 6-[4-amino-phenyl]pyridazin-3(2H)-one will be discussed in detail.

1. Raw Material Preparation
   The production of 6-[4-amino-phenyl]pyridazin-3(2H)-one begins with the preparation of raw materials, which includes the synthesis of 4-amino-phenyl)pyridine and 2,3-pyridinedione.
   The 4-amino-phenyl)pyridine is synthesized by reacting 4-aminophenol with chloroform using a condensation reaction.
   The product is then purified by recrystallization, and the resulting solid is used as the starting material for the next step.
   
2. Condensation Reaction
   The 2,3-pyridinedione is synthesized by a condensation reaction between pyridine-3-carboxaldehyde and acetone.
   The product is then purified by recrystallization and used as the starting material for the next step.
   
3. Nitration Reaction
   The 4-amino-phenyl)pyridine and 2,3-pyridinedione are then mixed and nitrated using a nitration reaction.
   The nitration reaction is carried out in the presence of a nitrating agent such as nitric acid, and the product is purified by recrystallization.
   
4. Reduction Reaction
   The nitro group of the product from the nitration reaction is then reduced using a reduction reaction.
   The reduction reaction is carried out in the presence of a reducing agent such as lithium aluminum hydride.
   The product is then purified by recrystallization and used as the starting material for the next step.
   
5. Coupling Reaction
   The reduced product from the reduction reaction is then coupled with the 2,3-pyridinedione using a coupling reaction.
   The coupling reaction is carried out using a coupling agent such as dicyclohexylcarbodiimide (DCC) and hydroxybenzotriazole (HOBT).
   The product is then purified by recrystallization and used as the starting material for the next step.
   
6. Final Purification
   The product from the coupling reaction is then purified by recrystallization.
   The resulting solid is then dried and ground to a fine powder.
   The powder is then recrystallized again using a suitable solvent.
   The final product is then dried and weighed to ensure purity.
   

In conclusion, the production process of 6-[4-amino-phenyl]pyridazin-3(2H)-one is a multi-step process that requires careful monitoring and control of the reaction conditions.
The quality of the starting materials and the purity of the product are critical for the success of the process.
The use of advanced purification techniques such as recrystallization, and the use of appropriate reaction conditions, can help to ensure the production of high-quality 6-[4-amino-phenyl]pyridazin-3(2H)-one.
The compound is an important intermediate in the synthesis of various active ingredients and is also used as a reagent in several chemical reactions, and its production process is widely used in the pharmaceutical, agrochemical, and other industries.