The Production Process of 6-(2-Hydroxyphenyl)-3(2H)-pyridazinone

6-(2-Hydroxyphenyl)-3(2H)-pyridazinone is a synthetic chemical compound that is commonly used in various industrial applications.
The production process of 6-(2-hydroxyphenyl)-3(2H)-pyridazinone involves several steps that are carried out in a controlled industrial setting.
In this article, we will provide an in-depth overview of the production process of 6-(2-hydroxyphenyl)-3(2H)-pyridazinone, including the raw materials required, the different stages of the process, and the safety measures that need to be taken into account.

Raw Materials Required for Production:

The production of 6-(2-hydroxyphenyl)-3(2H)-pyridazinone requires a number of raw materials.
The main raw material is 2-hydroxyphenyl acetate, which is a derivative of phenol.
Other raw materials required for the production process include pyridazine-3-carboxylic acid, sodium hydroxide, and a solvent such as toluene or benzene.

Production Process:

The production process of 6-(2-hydroxyphenyl)-3(2H)-pyridazinone involves several stages, including the following:

1. Preparation of the Reactants:
   The first step in the production process is the preparation of the reactants.
   In this case, 2-hydroxyphenyl acetate and pyridazine-3-carboxylic acid are prepared by separate chemical reactions.
   The 2-hydroxyphenyl acetate is prepared by reacting phenol with acetyl chloride in the presence of a solvent such as benzene.
   The pyridazine-3-carboxylic acid is prepared by reacting 3-pyridazinecarboxylic acid with sodium hydroxide in water.
   
2. The Reaction:
   The next step is the actual reaction between the two reactants.
   The 2-hydroxyphenyl acetate and pyridazine-3-carboxylic acid are mixed together in the presence of a solvent, such as toluene or benzene.
   The reaction is carried out at a moderate temperature, typically around 80-90°C, and is catalyzed by a strong acid catalyst such as sulfuric acid.
   
3. Isolation of Intermediate:
   After the reaction is complete, the intermediate product is isolated from the reaction mixture.
   This can be done by filtration, followed by washing with a solvent such as ethyl acetate.
   
4. Purification of the Product:
   The next step is the purification of the product.
   This is typically done using a chromatographic method, such as column chromatography, where the mixture is passed through a column packed with a stationary phase.
   The product is then eluted from the column using a solvent that has a gradual change in polarity.
   
5. Recrystallization:
   The purified product is then recrystallized to remove any impurities that may be present.
   This is typically done using a solvent such as ethanol, followed by filtration and drying.
   

Safety Measures:

The production of 6-(2-hydroxyphenyl)-3(2H)-pyridazinone is a chemical process that requires careful attention to safety measures.
The following precautions should be taken to ensure the safety of the workers involved in the production process:

1. Personal Protective Equipment:
   All workers involved in the production process should wear appropriate personal protective equipment, including gloves, safety glasses, and lab coats.
   
2. Proper Handling of Chemicals:
   All chemicals should be handled with care, and workers should be trained in the proper procedures for handling and storing chemicals.
   
3. Emergency Response Plan:
   An emergency response plan should be in place in case of any accidents or spills.
   This plan