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The production process of 5-methoxy-pyridine-2-ylamine is a multi-step process that involves several chemical reactions.
The starting material for the production of this compound is typically 3-methoxy-pyridine-2-carboxylic acid, which is obtained through the reaction of pyridine-2,3-dicarboxylic acid with methanol in the presence of a catalyst.
The first step in the production of 5-methoxy-pyridine-2-ylamine is the conversion of 3-methoxy-pyridine-2-carboxylic acid into 3-methoxy-pyridine-2-ylamine through the process of N-alkylation.
This is typically done using a primary amine, such as methylamine or ethylamine, in the presence of a catalyst, such as sodium hydroxide or potassium hydroxide.
The next step in the production process is the reduction of the nitrogen atom in the N-alkylated product to form the amine.
This is typically done using a reducing agent, such as lithium aluminum hydride (LiAlH4) or hydrogen in the presence of a catalyst, such as palladium on barium carbonate.
The final step in the production of 5-methoxy-pyridine-2-ylamine is the deprotection of the methoxy group.
This is typically done using a reagent such as hydrogen chloride or sodium hydroxide in the presence of a catalyst, such as ferric chloride.
The overall yield of 5-methoxy-pyridine-2-ylamine can vary depending on the specific reaction conditions and the purity of the starting material.
The product is typically purified by recrystallization or by chromatography using a suitable solvent, such as water or a polar solvent like ethanol.
In conclusion, the production of 5-methoxy-pyridine-2-ylamine is a multi-step process that involves several chemical reactions.
The process typically starts with the conversion of 3-methoxy-pyridine-2-carboxylic acid into 3-methoxy-pyridine-2-ylamine through N-alkylation, followed by reduction of the nitrogen atom and deprotection of the methoxy group.
The final product is typically purified by recrystallization or chromatography.
The overall yield of the product can vary depending on the specific reaction conditions and the purity of the starting material.
