The Production Process of 5-bromo-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,3-dimethoxybenzamide

The production process of 5-bromo-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,3-dimethoxybenzamide involves several steps, which are necessary to produce the final product in a controlled and efficient manner.
The following is a detailed description of the production process of 5-bromo-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,3-dimethoxybenzamide.

Step 1: Preparation of the starting material
The production of 5-bromo-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,3-dimethoxybenzamide begins by preparing the starting material.
The starting material for the production of 5-bromo-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,3-dimethoxybenzamide is 2,3-dimethoxybenzaldehyde.
This compound is synthesized by known methods in the chemical industry, such as the Sharpless epoxidation or the Mitsunobu reaction.

Step 2: Bromination of 2,3-dimethoxybenzaldehyde
In this step, 2,3-dimethoxybenzaldehyde is treated with a bromine source to introduce the bromine atom into the molecule.
The bromine source used in this reaction can be either sodium bromide or N-bromosuccinimide.
The reaction is typically carried out in the presence of a solvent, such as acetic acid or dichloromethane.
The bromination reaction is carried out under mild conditions, typically at room temperature or slightly elevated temperatures.
The bromination reaction is usually complete within 1-2 hours.

Step 3: N-alkylation of 5-bromo-2,3-dimethoxybenzamide
The next step in the production process of 5-bromo-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,3-dimethoxybenzamide is the N-alkylation of 5-bromo-2,3-dimethoxybenzamide.
The N-alkylation is carried out by treating 5-bromo-2,3-dimethoxybenzamide with a primary alkyl halide, such as methyl iodide or ethyl iodide.
The reaction is typically carried out in the presence of a solvent, such as DMF or DMSO.
The reaction is typically carried out at elevated temperatures, such as 80-100°C, for several hours.

Step 4: Ring closure of N-alkylated intermediate
The next step in the production process of 5-bromo-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,3-dimethoxybenzamide is the ring closure of the N-alkylated intermediate.
The ring closure is carried out by heating the N-alkylated intermediate under conditions that allow the formation of the final product.
The reaction is typically carried out in the presence of a solvent, such as toluene or xylene.
The reaction is typically carried out at elevated temperatures, such as 100-120°C, for several hours.

Step 5: Purification of the final product
The final product is typically purified by chromatography techniques, such as silica gel chromatography or high-performance liquid chromatography.
The purified final product is collected and dried, and the yield of the final product is measured.

Overall, the production process of 5-bromo-N-[(1-ethylpyrrolidin-2-yl)methyl]-2,3-dimethoxybenzamide involves several steps, which are necessary to produce the