The Production Process of 4-(thiazol-2-yl)pyriMidin-2-ol

4-(thiazol-2-yl)pyriMidin-2-ol is a synthetic compound that is commonly used in the pharmaceutical industry as a research chemical.
It is a type of thiophene derivative that has been shown to exhibit a range of biological activities, including antioxidant, anti-inflammatory, and neuroprotective effects.
The production process of 4-(thiazol-2-yl)pyriMidin-2-ol involves several steps, which are outlined below.

Step 1: Preparation of thiophene-2-carbaldehyde
The first step in the production of 4-(thiazol-2-yl)pyriMidin-2-ol is the preparation of thiophene-2-carbaldehyde.
This compound is synthesized by the reduction of thiophene-2-aldehyde using reducing agents such as lithium aluminum hydride (LiAlH4) or hydrogen in the presence of a catalyst, such as palladium on barium carbonate.
The reduction reaction is carried out in an inert solvent, such as ether or benzene, under anhydrous conditions.

Step 2: Condensation of thiophene-2-carbaldehyde with pyridine-3-aldehyde
The next step in the production of 4-(thiazol-2-yl)pyriMidin-2-ol is the condensation of thiophene-2-carbaldehyde with pyridine-3-aldehyde.
This reaction is carried out in the presence of a condensing agent, such as dimethylformamide (DMF), and a catalyst, such as triethylamine.
The reaction is typically carried out at an elevated temperature, such as 80-100°C, for several hours.
The resulting product is then isolated and purified by conventional methods, such as filtration, washing, and recrystallization.

Step 3: Nitration of the condensation product
The next step in the production of 4-(thiazol-2-yl)pyriMidin-2-ol is the nitration of the condensation product from step 2.
This is typically done using a nitrating agent, such as nitric acid or a nitrate salt, in the presence of a solvent, such as acetic acid or water.
The reaction is typically carried out at room temperature for several hours, after which the resulting product is isolated and purified as before.

Step 4: N-demethylation of the nitrated product
The final step in the production of 4-(thiazol-2-yl)pyriMidin-2-ol is the N-demethylation of the nitrated product from step 3.
This is typically done using a reductive agent, such as lithium aluminum hydride (LiAlH4), in the presence of a solvent, such as ether or benzene.
The reaction is typically carried out at an elevated temperature, such as 100-120°C, for several hours, after which the resulting product is isolated and purified by conventional methods.

Overall, the production process of 4-(thiazol-2-yl)pyriMidin-2-ol involves several steps, including the preparation of thiophene-2-carbaldehyde, the condensation of thiophene-2-carbaldehyde with pyridine-3-aldehyde, the nitration of the condensation product, and the N-demethylation of the nitrated product.
The resulting product is a synthetic compound that is commonly used in the pharmaceutical industry as a research chemical.
It has been shown to exhibit a range