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4’-Methyl[2,2’-bipyridine]-4-carboxylic acid, also known as 4-HPP, is an important intermediate in the production of various pharmaceuticals and chemical products.
The production process of 4-HPP involves several steps, including the synthesis of 2,2’-bipyridine, its conversion to 4-chloro-4’-methyl[2,2’-bipyridine], and the hydrolysis of the chloride to form 4’-methyl[2,2’-bipyridine]-4-carboxylic acid.
In this article, we will take a closer look at the production process of 4-HPP in the chemical industry.
Step 1: Synthesis of 2,2’-bipyridine
The synthesis of 2,2’-bipyridine is the first step in the production of 4-HPP.
This compound can be synthesized using several methods, including the classical method, which involves the reaction of picric acid with an amine, or the Johnson-Matthey method, which uses a one-pot procedure with dichloromethane and trimethylphosphine.
Step 2: Conversion of 2,2’-bipyridine to 4-Chloro-4’-methyl[2,2’-bipyridine]
The next step in the production of 4-HPP is the conversion of 2,2’-bipyridine to 4-chloro-4’-methyl[2,2’-bipyridine].
This can be done using conventional methods, such as the chlorination of 2,2’-bipyridine with bleach, or using alternative methods, such as the use of chlorinating agents like thionyl chloride.
Step 3: Hydrolysis of 4-Chloro-4’-methyl[2,2’-bipyridine] to 4’-Methyl[2,2’-bipyridine]-4-carboxylic acid
The final step in the production of 4-HPP is the hydrolysis of 4-chloro-4’-methyl[2,2’-bipyridine] to form 4’-methyl[2,2’-bipyridine]-4-carboxylic acid.
This can be done using hydrolysis methods such as acid hydrolysis or base hydrolysis.
Overall, the production process of 4-HPP involves several steps, including the synthesis of 2,2’-bipyridine, its conversion to 4-chloro-4’-methyl[2,2’-bipyridine], and the hydrolysis of the chloride to form 4’-methyl[2,2’-bipyridine]-4-carboxylic acid.
This compound is an important intermediate in the production of various pharmaceuticals and chemical products, and its synthesis requires careful attention to detail and the use of appropriate methods and materials.
