The Production Process of 4-(Dicyanomethylene)-2-tert-butyl-6-(1,1,7,7-tetramethyljulolidin-4-yl-vinyl)-4H-pyran

The Production Process of 4-(Dicyanomethylene)-2-tert-butyl-6-(1,1,7,7-tetramethyljulolidin-4-yl-vinyl)-4H-pyran in Chemical Industry

4-(Dicyanomethylene)-2-tert-butyl-6-(1,1,7,7-tetramethyljulolidin-4-yl-vinyl)-4H-pyran is an important intermediate in the production of several pharmaceuticals, agrochemicals, and other chemical products.
The compound is known for its excellent stability and activity, which makes it an ideal choice for various applications in the chemical industry.
In this article, we will discuss the production process of 4-(Dicyanomethylene)-2-tert-butyl-6-(1,1,7,7-tetramethyljulolidin-4-yl-vinyl)-4H-pyran in chemical industry.

1. Synthesis of Tetralin-2-amine
   The synthesis of Tetralin-2-amine, a key intermediate in the production of 4-(Dicyanomethylene)-2-tert-butyl-6-(1,1,7,7-tetramethyljulolidin-4-yl-vinyl)-4H-pyran, involves several steps.
   The process typically begins with the synthesis of N-methylaniline, which is then transformed into N-methyl-o-toluidine using a Friedel-Crafts reaction.
   The N-methyl-o-toluidine is then catalytically hydrogenated to form o-toluidine, which is the precursor for Tetralin-2-amine synthesis.
   The Tetralin-2-amine is then synthesized by reacting o-toluidine with formaldehyde in the presence of an acid catalyst.
   
2. Synthesis of 2-tert-Butyl-6-(1,1,7,7-tetramethyljulolidin-4-yl-vinyl)-4H-pyran
   The synthesis of 2-tert-Butyl-6-(1,1,7,7-tetramethyljulolidin-4-yl-vinyl)-4H-pyran involves several steps, including the synthesis of N-methyl-4-piperazidebenzamide, a key intermediate.
   N-methyl-4-piperazidebenzamide can be synthesized by reacting 4-nitrobenzaldehyde with dimethylamine in the presence of a solvent such as pyridine.
   The product is then hydrogenated to N-methyl-4-piperazidebenzamide.
   The next step involves the condensation of N-methyl-4-piperazidebenzamide with 2-tubyl-6-vinyl-4H-pyran in the presence of a Lewis acid catalyst such as AlCl3.
   The reaction is typically carried out at high temperatures and pressures to facilitate the reaction.
   
3. Synthesis of 4-(Dicyanomethylene)-2-tert-butyl-6-(1,1,7,7-tetramethyljulolidin-4-yl-vinyl)-4H-pyran
   The synthesis of 4-(Dicyanomethylene)-2-tert-butyl-6-(1,1,7,7-tetramethyljulolidin-4-yl-vinyl)-4H-pyran involves several steps, including the synthesis of N-methyl-4-(1,1,7,7-tetramethyljulolidin-4-yl-amide), a key intermediate.
   N-methyl-