The Production Process of 4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE

4-Chloro-6-methylthieno[2,3-d]pyrimidine, commonly referred to as 4-CMT, is a synthetic chemical compound that is widely used in various applications in the chemical industry.
It is a colorless solid that has a distinct, unpleasant odor and is soluble in water.
The production process of 4-CMT involves several steps, from the preparation of raw materials to the final product.

The first step in the production process is the preparation of the raw materials, which includes the synthesis of 2-amino-6-methylthiophenecarbonitrile.
This compound is reacted with chloroform to produce 2,6-dichloro-4-methylthiophenol, which is then treated with anhydrous hydrogen chloride to produce 4-chloro-6-methylthiophenol.

The next step is the reaction of 4-chloro-6-methylthiophenol with sodium hydrosulfite to produce 6-methylthiolinesulfonic acid, which is then converted to 6-methylthiolinesemicarbazide through a series of reactions.
This compound is then reduced with sodium metabisulfite to produce 6-methylthiolinesemicarbazide-5-one.

The next step in the production process is the nitration of 6-methylthiolinesemicarbazide-5-one with nitric acid to produce 4-chloro-6-methylthiopyrimidine-2,5-dione.
This compound is then cyclized with sodium hydroxide to produce 4-chloro-6-methylthiopyrimidine-2,3-dione.

Finally, the 4-chloro-6-methylthiopyrimidine-2,3-dione is treated with hydrogen chloride to produce the final product, 4-chloro-6-methylthiopyrimidine, which is then purified and packaged for use in various applications.

Due to its unpleasant odor, 4-CMT is often used in applications where a strong odor is not a concern, such as in the production of plastics and synthetic fibers.
It is also used as a reagent in organic synthesis and as a catalyst in the production of other chemical compounds.

The production process of 4-CMT involves several steps, each of which presents its own challenges in terms of efficiency, safety, and environmental impact.
Careful control of the reaction conditions and the use of appropriate safety measures are necessary to ensure the safe and efficient production of this important chemical.