The Production Process of (4-Chloro-5-methyl-pyrimidin-2-yl)-cyclopropyl-amine

The production process of (4-chloro-5-methyl-pyrimidin-2-yl)-cyclopropyl-amine involves several steps, each with its own specific challenges and considerations.
In order to produce this compound effectively and efficiently, it is important to have a clear understanding of the underlying chemical reactions and to carefully control the process parameters at each stage.

The first step in the production process is the synthesis of 2-[(4-chloro-5-methyl-pyrimidin-2-yl)amino]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine, which is a key intermediate in the synthesis of (4-chloro-5-methyl-pyrimidin-2-yl)-cyclopropyl-amine.
This intermediate can be synthesized using a variety of methods, such as the Strecker reaction or the Strain-Eckert reaction.

Once the intermediate has been synthesized, the next step is to convert it into (4-chloro-5-methyl-pyrimidin-2-yl)-cyclopropyl-amine.
This can be done using a variety of methods, such as hydrolysis or amidation.
The specific method chosen will depend on the desired yield and purity of the final product, as well as the availability of specialized equipment and reagents.

One potential method for the synthesis of (4-chloro-5-methyl-pyrimidin-2-yl)-cyclopropyl-amine is the hydrolysis of the intermediate using a strong acid catalyst, such as hydrochloric acid or sulfuric acid.
This method involves the deprotonation of the intermediate using the acid catalyst, followed by the addition of water to form the amine.
The reaction can be conducted at room temperature or at an elevated temperature, depending on the specific conditions and the desired yield.

Another potential method for the synthesis of (4-chloro-5-methyl-pyrimidin-2-yl)-cyclopropyl-amine is the amidation of the intermediate using a strong base, such as sodium hydroxide or potassium hydroxide.
This method involves the deprotonation of the intermediate using the base, followed by the addition of an amine, such as cyclopropylamine.
The reaction can be conducted at an elevated temperature, typically in the range of 100 to 150°C, depending on the specific conditions and the desired yield.

Overall, the production process of (4-chloro-5-methyl-pyrimidin-2-yl)-cyclopropyl-amine requires careful control of the reaction parameters and the use of specialized equipment and reagents.
By understanding the underlying chemical reactions and carefully controlling the process parameters, it is possible to produce this compound efficiently and cost-effectively.