The Production Process of (4-CHLORO-2-METHYLSULFANYL-PYRIMIDIN-5-YL)-METHANOL

The production process of (4-chloro-2-methylsulfanyl-pyrimidin-5-yl)-methanol is a multi-step chemical reaction that involves several intermediate steps and purification processes to obtain the final product.
This article will provide a detailed overview of the production process of (4-chloro-2-methylsulfanyl-pyrimidin-5-yl)-methanol.

Step 1: Preparation of 2-methylsulfanyl-5-nitro-pyrimidine
The first step in the production process of (4-chloro-2-methylsulfanyl-pyrimidin-5-yl)-methanol is the preparation of 2-methylsulfanyl-5-nitro-pyrimidine.
This compound is synthesized by reacting 2-methylsulfanyl-amino-pyrimidine with nitrous acid in the presence of a solvent such as water or ethyl acetate.

Step 2: Hydrolysis of 2-methylsulfanyl-5-nitro-pyrimidine
The next step in the production process of (4-chloro-2-methylsulfanyl-pyrimidin-5-yl)-methanol is the hydrolysis of 2-methylsulfanyl-5-nitro-pyrimidine to form 2-methylsulfanyl-5-amino-pyrimidine.
This reaction is carried out by treating 2-methylsulfanyl-5-nitro-pyrimidine with water in the presence of a catalyst such as sodium hydroxide.

Step 3: Nitration of 2-methylsulfanyl-5-amino-pyrimidine
The next step in the production process of (4-chloro-2-methylsulfanyl-pyrimidin-5-yl)-methanol is the nitration of 2-methylsulfanyl-5-amino-pyrimidine to form 4-chloro-2-methylsulfanyl-pyrimidine.
This reaction is carried out by treating 2-methylsulfanyl-5-amino-pyrimidine with nitrating reagents such as nitric acid or nitrous acid in the presence of a solvent such as acetonitrile or dichloromethane.

Step 4: Hydrolysis of 4-chloro-2-methylsulfanyl-pyrimidine
The next step in the production process of (4-chloro-2-methylsulfanyl-pyrimidin-5-yl)-methanol is the hydrolysis of 4-chloro-2-methylsulfanyl-pyrimidine to form 4-chloro-2-methylsulfanyl-5-amino-pyrimidine.
This reaction is carried out by treating 4-chloro-2-methylsulfanyl-pyrimidine with water in the presence of a catalyst such as sodium hydroxide.

Step 5: Dehydration of 4-chloro-2-methylsulfanyl-5-amino-pyrimidine
The next step in the production process of (4-chloro-2-methylsulfanyl-pyrimidin-5-yl)-methanol is the dehydration of 4-chloro-2-methylsulfanyl-5-amino-pyrimidine to form (4-chloro-2-methyls