The Production Process of 4-Bromo-2,8-bis(trifluoromethyl)quinoline

The Production Process of 4-Bromo-2,8-bis(trifluoromethyl)quinoline in the Chemical Industry

4-Bromo-2,8-bis(trifluoromethyl)quinoline (CAS 114663-96-2) is an organic compound commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other industrial chemicals.
The compound is known for its unique properties, such as its high stability and reactivity, which make it a valuable intermediate in the production of various chemicals.
In this article, we will discuss the production process of 4-bromo-2,8-bis(trifluoromethyl)quinoline, including the starting materials, reagents, and equipment required, as well as the various steps involved in the process.

Starting Materials

The starting materials required for the production of 4-bromo-2,8-bis(trifluoromethyl)quinoline include 2,8-bis(trifluoromethyl)quinoline and 4-bromoaniline.
These materials are readily available in the chemical industry and can be sourced from various suppliers.

Reagents

The following reagents are typically used in the production of 4-bromo-2,8-bis(trifluoromethyl)quinoline:

• Trifluoromethanesulfonic acid (TFMS)
• Sodium bicarbonate (NaHCO3)
• Sodium chloride (NaCl)
• Water

Equipment

The production process of 4-bromo-2,8-bis(trifluoromethyl)quinoline requires the use of various pieces of equipment, including:

• Mixing vessels
• Reactors
• Condensers
• Cooling jackets
• Filter presses
• Distillation apparatus

Procedure

The production process of 4-bromo-2,8-bis(trifluoromethyl)quinoline involves several steps, as outlined below:

Step 1: Mixing of Starting Materials

In this step, the starting materials, 2,8-bis(trifluoromethyl)quinoline and 4-bromoaniline, are mixed together in a mixing vessel.
The mixture is typically heated to a temperature of around 80-100°C to ensure complete dissolution of the starting materials.

Step 2: Addition of Reagents

Once the starting materials have been fully dissolved, trifluoromethanesulfonic acid (TFMS) is added to the mixture, followed by the addition of sodium bicarbonate.
The mixture is then cooled to a temperature of around 50-60°C.

Step 3: Reaction

The mixture from Step 2 is then reacted by slowly adding sodium chloride.
The reaction is typically carried out over a period of several hours, during which time the mixture is stirred continuously.

Step 4: Separation of Product

After the reaction is complete, the mixture is allowed to settle, and the liquid and solid components are separated.
The liquid phase is collected and filtered to remove any solid impurities.
The resulting filtrate is then washed with water to remove any remaining impurities.

Step 5: Distillation

The filtrate from Step 4 is then distilled to separate the desired product from any impurities.
The distillation is typically carried out under reduced pressure, using a condenser to cool the vapor.
The resulting liquid is then collected and further purified if necessary.

Yield and Purification

The yield of 4-bromo-2,8-bis(trifluoromethyl)quinoline obtained from this