The Production Process of 4,6-Dichloro-3-methyl-isoxazolo[5,4-d]pyrimidine

4,6-Dichloro-3-methyl-isoxazolo[5,4-d]pyrimidine, also known as chlorpactamide, is an antibiotic agent used to treat a variety of bacterial infections.
The production process of this compound involves several steps, including the synthesis of the individual components and their subsequent assembly.

The first step in the production of chlorpactamide involves the synthesis of 3-methyl-isoxazolo[5,4-d]pyrimidine, also known as 3-methyl-isoxazole-5-acetic acid.
This compound is synthesized by reacting 3-methyl-isoxazole with acetic anhydride in the presence of a catalyst, such as pyridine.
The reaction results in the formation of an acetamide, which is then hydrolyzed to produce the desired pyrimidine.

The next step in the production of chlorpactamide involves the synthesis of 4,6-dichloro-3-methyl-isoxazolo[5,4-d]pyrimidine.
This is accomplished by reacting 3-methyl-isoxazolo[5,4-d]pyrimidine with chloroform in the presence of a catalyst, such as thionyl chloride.
The resulting compound is then treated with a base, such as sodium hydroxide, to convert it to the desired form.

Once the individual components of chlorpactamide have been synthesized, they are combined in a final step to produce the final product.
This is typically done by mixing the 3-methyl-isoxazolo[5,4-d]pyrimidine and 4,6-dichloro-3-methyl-isoxazolo[5,4-d]pyrimidine in the presence of a solvent, such as ethanol or water.
The resulting mixture is then precipitated, washed, and dried to produce the final product.

Overall, the production process of chlorpactamide involves several steps, including the synthesis of the individual components and their subsequent assembly.
These steps require the use of a variety of chemicals and equipment, and the process must be carefully monitored to ensure that the final product meets the desired specifications.

Chlorpactamide is an important antibiotic agent that is used to treat a variety of bacterial infections.
The production process of this compound involves several steps, including the synthesis of the individual components and their subsequent assembly.
The first step in the production of chlorpactamide involves the synthesis of 3-methyl-isoxazolo[5,4-d]pyrimidine, which is then combined with 4,6-dichloro-3-methyl-isoxazolo[5,4-d]pyrimidine to produce the final product.
The production process requires the use of a variety of chemicals and equipment, and must be carefully monitored to ensure that the final product meets the desired specifications.