The Production Process of 4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester

The production process of 4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester involves a series of steps that convert the starting materials into the final product.
The following is a detailed description of the production process.

Step 1: Preparation of the starting material
The production of 4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester begins with the preparation of the starting material.
The starting material for this process is 3,5-dimethyl-1H-pyrrole-2-carboxylic acid, which is synthesized by a series of reactions involving the derivatization of pyrrole.

Step 2: Protection of the functional group
The next step in the production process is the protection of the functional group of the starting material.
The functional group of 3,5-dimethyl-1H-pyrrole-2-carboxylic acid is the carboxylic acid group, which is a highly reactive group that can undergo various reactions with other molecules.
To prevent this unwanted reactivity, the carboxylic acid group is protected with a protecting group.

The protecting group of choice for the carboxylic acid group is the tert-butyldimethylsilyl group.
This protecting group is added to the carboxylic acid group through a reaction with tert-butyldimethylsilyl chloride.
The protected molecule is then treated with a base to remove the protecting group from the carboxylic acid group.

Step 3: Amidation of the protected carboxylic acid
The protected carboxylic acid is then subjected to an amidation reaction, in which the carboxyl group reacts with an alcohol to form an amide.
The alcohol used in this reaction is 2-(diethylamino)ethanol, which is reacted with the protected carboxylic acid to produce 4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid.

Step 4: Deprotection of the protected carboxylic acid
After the amidation reaction, the protecting group on the carboxylic acid group is removed through a treatment with a reducing agent.
The reduced molecule is then treated with a strong acid to remove the remaining protecting group and produce the final product, 4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester.

Overall, the production process of 4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester involves the synthesis of the starting material, protection of the functional group, amidation of the protected carboxylic acid, and deprotection of the protected carboxylic acid.
These steps are carried out in a specific order to ensure the production of the desired product in high yield and purity.

Applications

4-[[[2-(Diethylamino)ethyl]amino]carbonyl]-3,5-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester is an important intermediate in the synthesis of certain pharmaceuticals and agrochemicals.
It has been shown to have potent insecticidal and acaricidal activity, making it a promising compound for the development of new pesticides.
The compound has also been shown to have antimicrobial activity, making it a potential candidate for the development of new antimicrobial agents.

Conclusion

The production process of 4-[[[2-(Diethylamino)ethyl]

번역결과
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